3622-30-8

Basic information

• Product Name: 2,4-Dichlorobenzothiazole
• Synonyms: 2,4-DICHLOROBENZOTHIAZOLE;2,4-DICHLORO-1,3-BENZOTHIAZOLE;IFLAB-BB F1910-0008;Benzothiazole, 2,4-dichloro- (7CI,8CI,9CI);Benzothiazole, 2,4-dichloro-;2,4-Dichlorobenzo[d]thiazole
• CAS NO: 3622-30-8
• Molecular Formula: C₇H₃Cl₂NS
• Molecular Weight: 204.08
• EINECS: 222-821-5
• Product Categories: BENZOTHIAZOLE
• Mol File: 3622-30-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 96-97 °C
• Boiling Point: 286.8 °C at 760 mmHg
• Flash Point: 127.2 °C
• Appearance: /
• Density: 1.568 g/cm³
• Vapor Pressure: 0.00446mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.02±0.10(Predicted)
• CAS DataBase Reference: 2,4-Dichlorobenzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichlorobenzothiazole(3622-30-8)
• EPA Substance Registry System: 2,4-Dichlorobenzothiazole(3622-30-8)

Safety Data

• Hazardous Substances Data: 3622-30-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow solid

InChI:InChI=1/C7H3Cl2NS/c8-4-2-1-3-5-6(4)10-7(9)11-5/h1-3H

Upstream product

• 21258-05-9 N-benzoyl-N'-(2-chlorophenyl)thiourea 
• 5344-82-1 o-chlorophenylthiourea 
• 4947-89-1 1-(3-chlorophenyl)-2-thiourea 
• 19952-47-7 4-chlorobenzo[d]thiazol-2-amine 
• 95-51-2 o-chloroaniline 

Downstream Products

• 70200-96-3 2,4-Dichlor-7-amino-benzthiazol 
• 39205-62-4 4-chlorobenzo[d]thiazol-2(3H)-one 
• 1340598-26-6 N-{2-[4-(aminosulfonyl)phenyl]ethyl}-1-(4-chloro-1,3-benzothiazol-2-yl)-3-piperidinecarboxamide 
• 51769-38-1 (4-chloro-1,3-benzothiazol-2-yl)hydrazine 
• 73443-77-3 4-chloro-2-methoxy-benzothiazole 
• 70200-91-8 2,4-Dichlor-7-nitro-benzthiazol 
• 3507-40-2 4-chloro-2-(methylsulfanyl)benzo[d]thiazole 

Relevant articles and documents

Self-assembly of a benzothiazolone conjugate into panchromatic fluorescent fibres and their application in cellular imaging

We report the synthesis and characterization of the structures formed by self-assembly of 4-chloro-2(3H)-benzothiazolone (CBT) into panchromatic fibres and their application in cellular imaging. The aggregation properties of the synthesized compound were studied extensively under different solvents and concentrations and their morphologies examined at a supramolecular level by various microscopic techniques such as atomic force microscopy (AFM), fluorescence microscopy, and optical microscopy. Interestingly, the self-assembled structures formed byCBTreveal panchromatic emission properties and show blue, green, and red fluorescence under different excitation wavelengths. The mechanism of structure formation of the self-assemblies was studied through different techniques such as concentration-dependent1H-NMR, ATR-FTIR, UV-visible spectroscopy, and fluorescence spectroscopy. Finally, the utility ofCBTfor cell imaging applications was demonstrated and it can be noted thatCBTwas efficiently taken up by mammalian cells and the cells revealed panchromatic emission in the blue, green, and red channels. The intensities of the fluorescence observed were blue > green > red and the dye interestingly does not exhibit any fluorescence quenching.

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles

The 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazole scaffold was selected as a central core structure for the discovery of novel antibacterial compounds. A systematic variation of the substituents on the oxo-pyrazole moiety, as well as on the benzo moiety, led to the creation of a small and focused library of benzothiazoles that was subjected to antibacterial screening. In a first round of screening, activity of the compounds against six representative microorganisms was established. For the most potent congeners, MIC values against S. aureus and P. aeruginosa were determined. The structure-activity relationship study clearly revealed that subtle structural variations influence the antibacterial activity to a large extent. The most potent congeners displayed MIC values of 3.30 μM.