36234-62-5

Basic information

• Product Name: Thiocyanic acid, 2-amino-4-phenyl-5-thiazolyl ester
• CAS NO: 36234-62-5
• Molecular Formula: C10H7N3S2
• Molecular Weight: 233.318
• Mol File: 36234-62-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thiocyanic acid, 2-amino-4-phenyl-5-thiazolyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Thiocyanic acid, 2-amino-4-phenyl-5-thiazolyl ester(36234-62-5)
• EPA Substance Registry System: Thiocyanic acid, 2-amino-4-phenyl-5-thiazolyl ester(36234-62-5)

Safety Data

• Hazardous Substances Data: 36234-62-5(Hazardous Substances Data)

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 540-72-7 sodium thiocyanide 
• 333-20-0 potassium thioacyanate 
• 1147550-11-5 ammonium thiocyanate 
• 16717-64-9 1-azidostyrene 
• 28241-61-4 ammonia thiocyanic acid 
• 163276-49-1 1-thiocyanatopyrrolidine-2,5-dione 

Downstream Products

• 75000-90-7 2-(2-nitro-benzylideneamino)-4-phenyl-5-thiocyanato-thiazole 
• 75000-85-0 2-(4-dimethylamino-benzylideneamino)-4-phenyl-5-thiocyanato-thiazole 
• 75000-91-8 3-[(4-phenyl-5-thiocyanato-thiazol-2-ylimino)-methyl]-phenol 
• 75000-87-2 2-methoxy-4-[(4-phenyl-5-thiocyanato-thiazol-2-ylimino)-methyl]-phenol 
• 75000-89-4 4-[(4-phenyl-5-thiocyanato-thiazol-2-ylimino)-methyl]-phenol 
• 75000-86-1 2-benzylideneamino-4-phenyl-5-thiocyanato-thiazole 
• 75012-52-1 2-(4-nitro-benzylideneamino)-4-phenyl-5-thiocyanato-thiazole 
• 75000-88-3 2-(2-chloro-benzylideneamino)-4-phenyl-5-thiocyanato-thiazole 
• 64689-62-9 5-(methylthio)-4-phenylthiazol-2-amine 
• 99970-50-0 N-(4-phenyl-5-thiocyanato-thiazol-2-yl)-acetamide 

Relevant articles and documents

ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light

An ARS-TiO2 photocatalyst has been prepared, by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark, to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazole, phenol, aniline, indole and pyrrole derivatives) were treated with the thiocyanate anion at room temperature. Herein, the first report on thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives under visible light is presented.

Metal-Free One-Pot Chemoselective Thiocyanation of Imidazothiazoles and 2-Aminothiazoles with in situ Generated N-Thiocyanatosuccinimide

A chemoselective thiocyanation of imidazothiazoles and 2-aminothiazoles with use of in situ generated N-thiocyanatosuccinimide (NTS) at room temperature is described. The protocol offers mild reaction conditions and high chemoselectivity for electrophilic substitution in imidazothiazoles over nucleophilic substitution. This method provides metal-free and easy conversion of imidazothiazoles and 2-aminothiazoles into their corresponding C-3 and C-5 thiocyanates, respectively, in good to excellent yield. The present protocol also offers the effective thiocyanation of bifunctional imidazothiazoles containing aliphatic -OH and C(sp 2)-H bond functionalities.

Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts

A highly selective construction of 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles, respectively, catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiocyanate has been developed. Use of readily available starting materials, high selectivity, as well as mild reaction conditions make this practical method particularly attractive.