36256-78-7

Upstream product

• 76562-25-9 2-(2-benzoylhydrazino)-4-carboxymethylidene-4,5-dihydrothiazoline 
• 98360-07-7 1-(2-phenyl)-3-thiosemicarbazide 
• 78-95-5 chloroacetone 
• 74087-90-4 2-Benzoylmethylthio-5-phenyl-1,3,4-oxadiazol 
• 66870-61-9 ethyl 2-(2-benzoylhydrazino)thiazole-4-acetate 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 
• 81555-88-6 1-(5-Phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-propan-2-one 

Relevant academic research and scientific papers

Ring Transformation of 1,3,4-Oxadiazole to s-Triazole-Fused Heterocycles. New Synthetic Route for Thiazolo-s-triazole and 7H-s-Triazolothiadiazine

s-Triazole-fused heterocycles have been synthesized by an intramolecular transformation of some 1,3,4-oxadiazole ketones with ammonia or hydrazine.The α- ketone 2m gave thiazolo-s-triazole (4m), accompanied by a small amount of the hydrazide 9m on treatment with ammonium acetate in acetic acid.Similar treatment of ketones 2a and 2b afforded only the hydrazides 9a and 9b, respectively.Ketones 2a-n reacted with hydrazine hydrate in acetic acid to give 7H-s-triazolothiadiazines 5a-n.However, ketones 2o-q, with substituents α to the carbonyl group, could not be converted to the corresponding fused-ring systems.Mechanisms for these transformations are proposed.

Nitrosation and Hydrolysis Studies of some Thiazole-4-acetic Esters

Nitrosation of hydrazino substituted thiazole-4-acetates has been shown to occur on the ring, rather than the α-methylene carbon, as previously reported.Thus nitrosation of ethyl 2-isopropylidenehydrazono-, 2-benzylidenehydrazono-, 2-(2-benzoylhydrazino)-