74087-90-4

Basic information

• Product Name: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
• Synonyms: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
• CAS NO: 74087-90-4
• Molecular Formula: C₁₆H₁₂N₂O₂S
• Molecular Weight: 296.34368
• Mol File: 74087-90-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone(74087-90-4)
• EPA Substance Registry System: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone(74087-90-4)

Safety Data

• Hazardous Substances Data: 74087-90-4(Hazardous Substances Data)

Upstream product

• 3004-42-0 5-phenyl-1,3,4-oxadiazole-2(3H)-thione 
• 70-11-1 α-bromoacetophenone 
• 613-94-5 benzoic acid hydrazide 
• 93-58-3 benzoic acid methyl ester 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 

Downstream Products

• 36256-78-7 2-(2-benzoylhydrazino)-4-methylthiazole 
• 81555-88-6 1-(5-Phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-propan-2-one 
• 81556-02-7 1,2-Diphenyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-ethanone 
• 81556-00-5 1-Phenyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-propan-1-one 
• 81556-01-6 2-(5-Phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-cyclohexanone 
• 81556-03-8 2-<(3-oxobutyl)thio>-5-phenyl-1,3,4-oxadiazole 
• 81556-04-9 3-phenyl-6-methyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine 
• 863301-82-0 2-bromo-1-phenyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-ethanone 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 
• 81556-13-0 Benzoic acid N'-(4-phenyl-thiazol-2-yl)-hydrazide 
• 79074-65-0 3,6-diphenyl<1,2,4>triazolo<3,4-b><1,3,4>thiadiazine 

Relevant articles and documents

Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities

The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a-41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%.

The reaction of 5-aryl-(hetaryl)-2-aroylmethylthio-1,3,4-oxadiazoles with aryldiazonium tetrafluoroborates

5-Aryl(hetaryl)-2-aroylmethylthio-1,3,4-oxadiazoles behave as CH acids and readily react with aryldiazonium tetrafluoroborates at the active methylene group to give azo coupling products. The spectroscopic properties of the compounds synthesized have been

Ring Transformation of 1,3,4-Oxadiazole to s-Triazole-Fused Heterocycles. New Synthetic Route for Thiazolo-s-triazole and 7H-s-Triazolothiadiazine

s-Triazole-fused heterocycles have been synthesized by an intramolecular transformation of some 1,3,4-oxadiazole ketones with ammonia or hydrazine.The α- ketone 2m gave thiazolo-s-triazole (4m), accompanied by a small amount of the hydrazide 9m on treatment with ammonium acetate in acetic acid.Similar treatment of ketones 2a and 2b afforded only the hydrazides 9a and 9b, respectively.Ketones 2a-n reacted with hydrazine hydrate in acetic acid to give 7H-s-triazolothiadiazines 5a-n.However, ketones 2o-q, with substituents α to the carbonyl group, could not be converted to the corresponding fused-ring systems.Mechanisms for these transformations are proposed.