36256-87-8Relevant academic research and scientific papers
Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes
Bole, Leonie J.,Davin, Laia,Kennedy, Alan R.,McLellan, Ross,Hevia, Eva
supporting information, p. 4339 - 4342 (2019/04/26)
A series of new Mg(ii) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C-F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C-N bonds via nucleophilic substitution.
ALKALINE METAL FLUORIDES IN GRAPHITE - NEW CATALYSTS IN ORGANIC SYNTHESIS. I. REACTIONS OF POLYFLUOROAROMATIC COMPOUNDS WITH O- AND N-NUCLEOPHILIC AGENTS
Aksenov, V. V.,Vlasov, V. M.,Danilkin, V. I.,Rodionov, P. P.,Shnitko, G. N.
, p. 57 - 73 (2007/10/02)
The paper reports the use of new catalysts - alkaline metal fluorides in graphite of the general formula C8MF, where M=Li, Na, K, Rb or Cs, in the reactions of polyfluoroaromatic compounds with aromatic OH-acids and piperidine.These compounds are shown to have a high activity in the above processes, exceeding that of similar free fluorides of alkaline metals.
Quantitative estimation of the reactivity of perfluorinated methylbenzenes and benzocycloalkenes in nucleophilic substitution reactions
Rodionov, Peter P.,Osina, Ol'Ga I.,Platonov, Vyacheslav E.,Yakobson, Georg G.
, p. 986 - 993 (2007/10/02)
The kinetics of the reactions of perfluorinated xylenes, mesitylene, p-cymene, benzocycloalkenes (benzocyclobutene, indane, tetralin) and octafluoronaphthalene with sodium methoxide and piperidine have been studied.Rate constants of the reactions of perfluorinated aromatic compounds with sodium methoxide (taking into account one reaction centre) are shown to incease in the order: hexafluorobenzene perfluoro-p-xylene ca.= perfluoro-p-cymene octafluorotoluene ca.= perfluoro-m-xylene perfluoromesitylene ca.= perfluoro-o-xylene.In the reactions with piperidine, a different sequence was observed: hexafluorobenzene perfluoro-p-xylene perfluoro-p-cymene perfluoromesitylene perfluoro-m-xylene octafluorotoluene perfluoro-o-xylene.In the reactions of perfluorobenzocycloalkenes with sodium methoxide and piperidine, the reactivity grows by about a factor of 2 with increase of the perfluoroalicyclic ring size by one CF2-group, in the following order: perfluorobenzocyclobutene perfluoroindan perfluorotetralin.
