362610-31-9Relevant academic research and scientific papers
Facile synthesis of optically active imidazole derivatives
Marek, Ales,Kulhanek, Jiri,Ludwig, Miroslav,Bures, Filip
, p. 1183 - 1190 (2008/02/07)
Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the
Chiral imidazole derivatives synthesis from enantiopure N-protected α-amino acids
Bures, Filip,Kulhanek, Jiri
, p. 1347 - 1354 (2007/10/03)
A route to the preparation of enantiopure ligands based on a 2-phenylimidazol ring is described. The stereogenic centre is placed into the chain bonded to the fourth carbon of the imidazole ring. The synthesis starts from inexpensive and readily available
Highly stereoselective synthesis of anti-N-protected-α-amino epoxides
Hoffman,Weiner,Maslouh
, p. 5790 - 5795 (2007/10/03)
A simple and efficient method for the synthesis of anti-N-protected amino epoxides from carbamate-protected amino acids is described. The two key steps are the monobromination of a β-ketoester and chelation-controlled reduction of a bromomethyl ketone intermediate. Good overall yields, high diastereoselectivity, and excellent functional group compatibility are characteristic.
