362610-35-3Relevant academic research and scientific papers
Highly stereoselective synthesis of anti-N-protected-α-amino epoxides
Hoffman,Weiner,Maslouh
, p. 5790 - 5795 (2001)
A simple and efficient method for the synthesis of anti-N-protected amino epoxides from carbamate-protected amino acids is described. The two key steps are the monobromination of a β-ketoester and chelation-controlled reduction of a bromomethyl ketone intermediate. Good overall yields, high diastereoselectivity, and excellent functional group compatibility are characteristic.
