362677-94-9Relevant articles and documents
A simple construction of 2-phenylimino-1,3-thiazolidin-4-ones
Hahn, Hoh-Gyu,Nam, Kee Dal,Mah, Heduck
, p. 1283 - 1289 (2007/10/03)
A new methodology for the construction of 2-phenylimino-1,3-thiazolidin-4-one skeleton is described. Reaction of maleic anhydride (5a) or maleimides (5b, 5c) with thiourea (6) gave the corresponding 2-imino-1,3-thiazolidin-4-ones (7) and (9) respectively. The reaction proceeded with high yield in polar solvents. In non-polar solvents at high temperature, however, isothiocyanate (8) was formed as a by-product presumably by the pyrolysis of thiourea (6). The proposed mechanism of the reaction was discussed.