36268-70-9

Usage

Synonyms

MSLI-015

Chemical Class

Nitrile derivative

Parent Compound

2-(methylsulfonamido)phenylacetic acid

Properties

+ Anti-inflammatory
+ Antitumor

Potential Uses

+ Cancer treatment
+ Autoimmune disease treatment
+ Inflammatory condition treatment

Mechanism of Action

+ Inhibition of pro-inflammatory mediators and cytokines production

Significance

+ Potential in the development of new pharmaceuticals

Upstream product

• 2973-50-4 2-aminophenylacetonitrile 
• 124-63-0 methanesulfonyl chloride 

Relevant academic research and scientific papers

Novel thiourea derivatives and the pharmaceutical compositions containing the same

The present invention relates to novel thiourca derivatives as a modulator for vanilloid receptor (VR) and the phar- maceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflam- matory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.