362703-68-2

Upstream product

• 362703-59-1 {4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-piperidin-4-yl}-acetic acid methyl ester 
• 64-19-7 acetic acid 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 169206-65-9 1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylene]piperidine 
• 362703-58-0 4-methoxycarbonylmethyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester 
• 362703-57-9 tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

A novel series of achiral TNF-α converting enzyme (TACE) inhibitors has been discovered. These compounds exhibited activities from 0.35 to 11 nM in a porcine TACE assay and inhibited TNF-α production in an LPS-stimulated whole blood assay with an IC5

Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha

The present application describes novel β-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3