362718-59-0Relevant articles and documents
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity
Friesen, Richard W.,Ducharme, Yves,Ball, Richard G.,Blouin, Marc,Boulet, Louise,C?té, Bernard,Frenette, Richard,Girard, Mario,Guay, Daniel,Huang, Zheng,Jones, Thomas R.,Laliberté, France,Lynch, Joseph J.,Mancini, Joseph,Martins, Evelyn,Masson, Paul,Muise, Eric,Pon, Douglas J.,Siegl, Peter K. S.,Styhler, Angela,Tsou, Nancy N.,Turner, Mervyn J.,Young, Robert N.,Girardt, Yves
, p. 2413 - 2426 (2007/10/03)
A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFα in human whole blood, the binding affinity