36278-54-3Relevant academic research and scientific papers
Preparation of Optically Enriched Secondary Alkyllithium and Alkylcopper Reagents—Synthesis of (?)-Lardolure and Siphonarienal
Morozova, Varvara,Skotnitzki, Juri,Moriya, Kohei,Karaghiosoff, Konstantin,Knochel, Paul
supporting information, p. 5516 - 5519 (2018/04/02)
Optically enriched secondary alkyl iodides were converted into secondary alkyllithium and secondary alkylcopper compounds with very high retention of configuration. Quenching with various electrophiles, including chiral epoxides, provided a range of chira
Dynamic kinetic asymmetric cross-benzoin additions of β-stereogenic α-keto esters
Goodman, C. Guy,Johnson, Jeffrey S.
supporting information, p. 14698 - 14701 (2014/12/11)
The dynamic kinetic resolution of β-halo α-keto esters via an asymmetric cross-benzoin reaction is described. A chiral N-heterocyclic carbene catalyzes the umpolung addition of aldehydes to racemic α-keto esters. The resulting fully substituted β-halo glycolic ester products are obtained with high levels of enantio- and diastereocontrol. The high chemoselectivity observed is a result of greater electrophilicity of the α-keto ester toward the Breslow intermediate. The reaction products are shown to undergo highly diastereoselective substrate-controlled reduction to give highly functionalized stereotriads.
GLYCOSIDASE INHIBITORS AND USES THEREOF
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Page/Page column 32; 33, (2014/07/21)
The compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds are provided. The methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc are also provided.
Fused pyridine derivatives
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Example 106, (2010/01/30)
The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.
Certain 1H-imidazol-1-yl-1-lower-alkanoic acid derivatives having anti-thrombotic activity
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, (2008/06/13)
Compounds of the general formula STR1 and pharmaceutically acceptable salts thereof have antithrombotic activity. Het represents 1-[1H-imidazolyl], 1-N-morpholinyl or pyridyl. A representative compound is 6-[2-(1H-Imidazol-1-yl)-1-yl-1-[[(4-methoxyphenyl)methoxy]methyl]ethoxy]hexanoic acid.
