36296-69-2

Upstream product

• 186581-53-3 diazomethane 
• 1466-73-5 trans-4-phenylcyclohexanecarboxylic acid 
• 67-56-1 methanol 
• 61414-79-7 methyl 2,3,4,5-tetrahydro-[1,1′-biphenyl]-4-carboxylate 
• 201230-82-2 carbon monoxide 

Downstream Products

• 87073-90-3 ((1r,4r)-4-phenylcyclohexyl)methanol 
• 117736-03-5 trans-4-(4-nitro-phenyl)-cyclohexane-carboxylic acid-⁽¹⁾-methyl ester 
• 83811-73-8 trans-4-phenylcyclohexylmethanol 
• 86236-86-4 trans-4-(4-acetoxy-phenyl)-cyclohexane-carboxylic acid-⁽¹⁾-methyl ester 
• 113524-42-8 acido trans-4-(4-nitrofenil)cicloesancarbossilico 
• 117735-83-8 trans-4-(4-amino-phenyl)-cyclohexane-carboxylic acid-⁽¹⁾-methyl ester 
• 111993-10-3 trans-4-(4-hydroxy-phenyl)-cyclohexane-carboxylic acid-⁽¹⁾ 

Relevant academic research and scientific papers

Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO

This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.

Discovery of 6-phenylpyrimido[4,5- B ][1,4]oxazines as potent and selective Acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents

The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discovery of phenylcyclohexylacetic acid 1, which displayed good DGAT1 inhibitory activity, selectivity, and PK properties. During preclinical toxicity studies a metabolite of 1 was observed that was responsible for elevating the levels of liver enzymes ALT and AST. Subsequently, analogues were synthesized to preclude the formation of the toxic metabolite. This effort resulted in the discovery of spiroindane 42, which displayed significantly improved DGAT1 inhibition compared to 1. Spiroindane 42 was well tolerated in rodents in vivo, demonstrated efficacy in an oral triglyceride uptake study in mice, and had an acceptable safety profile in preclinical toxicity studies.

LIQUID CRYSTAL COMPOUNDS AND METHOD FOR PREPARING THE SAME

The present invention relates to a liquid crystal compound for liquid crystal display. More particularly, the present invention provides a vinylcyclohexylbenzene, its derivatives and the preparation method thereof where the present invention produces only