363-34-8

Basic information

• Product Name: (2-FLUORO-BENZOYLAMINO)-ACETIC ACID
• Synonyms: 2-(2-FluorobenzaMido)acetic acid;2-[(2-fluorobenzoyl)amino]acetic acid;2-[(2-fluorophenyl)carbonylamino]ethanoic acid;2-[[(2-fluorophenyl)-oxomethyl]amino]acetic acid;N-(2-fluorobenzoyl)glycine;(2-fluorobenzoyl)glycine
• CAS NO: 363-34-8
• Molecular Formula: C₉H₈FNO₃
• Molecular Weight: 197.17
• Mol File: 363-34-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 412.7°Cat760mmHg
• Flash Point: 203.4°C
• Appearance: /
• Density: 1.358g/cm³
• Vapor Pressure: 1.5E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2-FLUORO-BENZOYLAMINO)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-FLUORO-BENZOYLAMINO)-ACETIC ACID(363-34-8)
• EPA Substance Registry System: (2-FLUORO-BENZOYLAMINO)-ACETIC ACID(363-34-8)

Safety Data

• Hazardous Substances Data: 363-34-8(Hazardous Substances Data)

Usage

General Description

(2-Fluoro-benzoylamino)-acetic acid is a chemical compound with the molecular formula C9H8FNO3. It is a derivative of benzoic acid and is commonly used in the synthesis of pharmaceuticals and other organic compounds. (2-FLUORO-BENZOYLAMINO)-ACETIC ACID has a fluorine atom attached to the benzene ring, which can affect its reactivity and biological activity. It is known to have potential applications in medicinal chemistry and drug discovery due to its unique chemical structure. However, further research is needed to fully understand its properties and potential uses in various fields.

InChI:InChI=1/C9H8FNO3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5H2,(H,11,14)(H,12,13)/p-1

Upstream product

• 304657-05-4 C₁₁H₁₂FNO₃ 
• 393-52-2 2-Fluorobenzoyl chloride 
• 56-40-6 glycine 

Downstream Products

• 1224962-87-1 C₁₁H₁₀FNO₄ 
• 313649-64-8 4-(4-nitrobenzylidene)-2-(2-fluorophenyl)-5(4H)-oxazolone 
• 313649-68-2 4-(4-methoxybenzylidene)-2-(2-fluorophenyl)-5(4H)-oxazolone 
• 105669-20-3 2-(2-fluorophenyl)-2-oxazoline-5-one 

Relevant articles and documents

Design, synthesis and evaluation of novel phenyl propionamide derivatives as non-nucleoside hepatitis B virus inhibitors

As an ongoing search for potent non-nucleoside anti-HBV agents with novel structures, we described a series of phenyl propionamide derivatives (3a-b, 4a-e, 7a-g, 8a-h and 9a-b) by pharmacophore fusion strategy in the present work. All the compounds exhibited an anti-HBV activity to some extent. Among them, compounds 8d and 9b displayed most potent anti-HBV activity with IC50 values on HBV DNA replication of 0.46 and 0.14 μM, respectively. And the selective index values of 8d and 9b were more than 217.39 and 153.14, suggesting that 8d and 9b exhibited favorable safety profiles. Interestingly, 8d and 9b possessed significantly antiviral activities against lamivudine and entecavir resistant HBV mutants with IC50 values of 0.77 and 0.32 μM. Notably, preliminary anti-HBV action mechanism studies showed that 8d could inhibit intracellular HBV pgRNA and RT activity of the HBV polymerase. Molecular docking studies suggested that compound 8d could fit into the dimer-dimer interface of HBV core protein by hydrophobic interaction. In addition, in silico prediction of physicochemical properties showed that 8d conformed well to the Lipinski's rule of five, suggesting its potential for use as a drug like molecule. Taken together, 8d possessed significantly anti-HBV activity, low toxicity, diverse anti-HBV mechanism and favorable physicochemical properties, and warranted further investigation as a promising non-nucleoside anti-HBV candidate.

Substituents effect on the erlenmeyer-ploechl reaction: Understanding an observed process reaction time

A systematic study on hippuric acid substituents was performed in order to better understand the influence of stereoelectronic factors on the Erlenmeyer reaction rate. In addition, two reaction systems were evaluated: Huenig's base solvent free conditions and catalytic sodium acetate in 2-methyl-THF. The effect on reaction rate of electron withdrawing and electron donating groups are reported. Specifically, the study led to the conclusion that stereoelectronic factors have significant influence in one of our key Erlenmeyer reaction by affecting its reaction rate.