363-80-4

Basic information

• Product Name: 2,3,5-TRIFLUOROANILINE
• Synonyms: 2,3,5-TRIFLUOROANILINE;2,3,5-Trifluoroaniline 98%;2,3,5-Trifluoroaniline98%;2,3,5-Trifluorobenzenamine
• CAS NO: 363-80-4
• Molecular Formula: C₆H₄F₃N
• Molecular Weight: 147.1
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aniline
• Mol File: 363-80-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 175℃
• Flash Point: 69℃
• Appearance: /
• Density: 1.409
• Vapor Pressure: 1.17mmHg at 25°C
• Refractive Index: 1.4895
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.18±0.10(Predicted)
• CAS DataBase Reference: 2,3,5-TRIFLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-TRIFLUOROANILINE(363-80-4)
• EPA Substance Registry System: 2,3,5-TRIFLUOROANILINE(363-80-4)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 363-80-4(Hazardous Substances Data)

Usage

General Description

2,3,5-Trifluoroaniline is a chemical compound with the molecular formula C6H4F3N. It is a derivative of aniline, a type of aromatic amine, in which three of the hydrogen atoms in the benzene ring are substituted with fluorine atoms. 2,3,5-TRIFLUOROANILINE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is a colorless to light yellow liquid with a strong, pungent odor. 2,3,5-Trifluoroaniline is considered to be toxic and hazardous, with potential adverse effects on human health and the environment. It should be handled with caution and in compliance with safety regulations.

InChI:InChI=1/C6H4F3N/c7-3-1-4(8)6(9)5(10)2-3/h1-2H,10H2

Upstream product

• 66684-57-9 1,2,5-trifluoro-3-nitrobenzene 
• 62-53-3 aniline 
• 2367-82-0 1,2,3,5-tetrafluorobenzene 
• 152402-36-3 4-amino-2,5,6-trifluoroisophthalic acid diamide 
• 1766-14-9 N-(2,3,5,6-tetrafluorophenyl)acetamide 

Downstream Products

• 2367-82-0 1,2,3,5-tetrafluorobenzene 
• 2268-15-7 2,3,5-trifluorophenol 
• 25170-73-4 2,5-difluoro-1,3-phenylenediamine 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 367-23-7 1,2,4-trifluorobenzene 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 1296271-97-0 N,N-dimethyl-2-morpholino-4-oxo-8-(1-(2,3,5-trifluorophenylamino)ethyl)-4H-chromene-6-carboxamide 
• 1382223-35-9 2-oxo-2-phenyl-N-(2,3,5-trifluorophenyl)acetamide 
• 1257629-85-8 C₁₃H₁₁F₃N₂O₃ 
• 1304511-82-7 N,N'-bis(2,3,5-trifluorophenyl)formamidine 
• 321-93-7 (2,3,5-trifluoro-phenoxy)-acetic acid 

Relevant articles and documents

Well-constructed Ni@CN material derived from di-ligands Ni-MOF to catalyze mild hydrogenation of nitroarenes

1,3,5-benzenetricarboxylate (BTC) and 4,4′-bipyridine (BIPY) are employed in the synthesis of dual ligands Ni-MOFs. The magnetic Ni@CN nanocatalyst is prepared by direct pyrolysis of Ni-MOFs in N2 atmosphere, which exhibited excellent activity

Efficient preparation method of 2, 4, 5-trifluorophenylacetic acid

The invention discloses an efficient preparation method of 2, 4, 5-trifluorophenylacetic acid and belongs to the technical field of synthesis of a pharmaceutical intermediate. The preparation method comprises synthesis of 2, 3, 5-trifluoroaniline, synthesis of 1, 2, 4-trifluorobenzene, synthesis of trifluorobromobenzene and synthesis of a desired product 2, 4, 5-trifluorophenylacetic acid. The preparation method is simple and easy to operate, utilizes cheap and easily available raw materials and has high reaction efficiency and good repeatability.

Interaction of polyfluorinated 2-chloroquinolines with ammonia

We have studied the interaction of polyfluorinated (in the benzene moiety) 2-chloroquinolines with liquid and aqueous ammonia as an approach to the synthesis of halogen-containing aminoquinolines. 5,7-Difluoro-, 5,6,8-trifluoro-, and 5,7,8-trifluoro-2-chloroquinolines mostly form products of substitution of the Cl atom, whereas 5,7-difluoro-2,6-dichloroquinoline, 5,6,7,8-tetrafluoro-, and 6,7-difluoro-2-chloroquinolines yield products of substitution of an F atom at various positions. The replacement of liquid ammonia with aqueous causes an increase in the proportion of the products of aminodechlorination relative to the products of aminodefluorination. For 2-chloro-6,8-difluoroquinoline this replacement leads to 2-amino-6,8-difluoroquinoline as the main product instead of the 8-amino-derivative. Activation energy values estimated by DFT calculations for the reactions in question agree with the reaction regioselectivity observed experimentally.