815610-16-3 Usage
Uses
Used in Pharmaceutical Synthesis:
4-Iodopyrimidin-2-amine is used as a building block in the preparation of various bioactive molecules. Its presence in the synthesis process contributes to the development of pharmaceuticals with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Iodopyrimidin-2-amine is utilized as a versatile intermediate. The combination of its amine and iodine groups facilitates the creation of a broad spectrum of novel compounds, which can be further explored for their medicinal properties or other scientific applications.
Used in Medicinal Research:
4-Iodopyrimidin-2-amine plays a significant role in medicinal research, where it is employed to develop new compounds with potential therapeutic effects. Its unique structure allows researchers to investigate its interactions with biological targets and its potential to address various health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 815610-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,5,6,1 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 815610-16:
(8*8)+(7*1)+(6*5)+(5*6)+(4*1)+(3*0)+(2*1)+(1*6)=143
143 % 10 = 3
So 815610-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H4IN3/c5-3-1-2-7-4(6)8-3/h1-2H,(H2,6,7,8)
815610-16-3Relevant academic research and scientific papers
Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors
Reichelt, Andreas,Bailis, Julie M.,Bartberger, Michael D.,Yao, Guomin,Shu, Hong,Kaller, Matthew R.,Allen, John G.,Weidner, Margaret F.,Keegan, Kathleen S.,Dao, Jennifer H.
, p. 364 - 382 (2014/05/20)
The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.
Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction
Walker, Scott R.,Czyz, Milena L.,Morris, Jonathan C.
supporting information, p. 708 - 711 (2014/03/21)
A synthesis of natural and synthetic members of the meridianin family of kinase inhibitory natural products has been developed. The sequence utilizes a variation of the Cacchi palladium-catalyzed domino reaction to efficiently construct the heterocyclic f
