363192-27-2

Upstream product

• 312638-87-2 4-cyclohexyl-4-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester 
• 363192-22-7 4-cyclohexyl-4-formyl-piperidine-1-carboxylic acid tert-butyl ester 
• 363192-26-1 4-cyclohexyl-4-[(2-hydroxy-1-methyl-ethylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 401843-81-0 {(R)-1-(4-Chloro-benzyl)-2-[4-cyclohexyl-4-((S)-4-methyl-2-oxo-oxazolidin-3-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester 
• 782442-42-6 (S)-3-{1-[(R)-2-Amino-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidin-4-ylmethyl}-4-methyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.

PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders r

SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS

Certain novel 4-substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.