363192-59-0Relevant academic research and scientific papers
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist
Hong, Qingmei,Bakshi, Raman K.,Palucki, Brenda L.,Park, Min K.,Ye, Zhixiong,He, Shuwen,Pollard, Patrick G.,Sebhat, Iyassu K.,Liu, Jian,Guo, Liangqin,Cashen, Doreen E.,Martin, William J.,Weinberg, David H.,MacNeil, Tanya,Tang, Rui,Tamvakopoulos, Constantin,Peng, Qianping,Miller, Randy R.,Stearns, Ralph A.,Chen, Howard Y.,Chen, Airu S.,Strack, Alison M.,Fong, Tung M.,MacIntyre, D. Euan,Wyvratt, Matthew J.,Nargund, Ravi P.
scheme or table, p. 2330 - 2334 (2011/05/15)
We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.
MELANOCORTIN RECEPTOR AGONISTS
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Page/Page column 57, (2010/02/11)
The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists
Bakshi, Raman K.,Hong, Qingmei,Olson,Ye, Zhixiong,Sebhat, Iyassue K.,Weinberg, David H.,MacNeil, Tanya,Kalyani, Rubana N.,Tang, Rui,Martin, William J.,Strack, Alison,McGowan, Erin,Tamvakopoulos, Constantin,Miller, Randy R.,Stearns, Ralph A.,Tang, Wei,Maclntyre, D. Euan,Van Der Ploeg, Lex H. T.,Patchett, Arthur A.,Nargund, Ravi P.
, p. 3430 - 3433 (2007/10/03)
The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.
