36321-43-4

Basic information

• Product Name: N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE
• Synonyms: N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE;N-(2-AMinoethyl)-1-naphthylacetaMide;Naphazoline EP Impurity A;N-(2-Aminoethyl)-1-naphthaleneacetamide
• CAS NO: 36321-43-4
• Molecular Formula: C14H16N2O
• Molecular Weight: 228.28964
• Product Categories: Amines, Aromatics, Metabolites & Impurities
• Mol File: 36321-43-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 491.7°Cat760mmHg
• Flash Point: 251.2°C
• Appearance: /
• Density: 1.147g/cm³
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE(36321-43-4)
• EPA Substance Registry System: N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE(36321-43-4)

Safety Data

• Hazardous Substances Data: 36321-43-4(Hazardous Substances Data)

Usage

Uses

N-(2-Aminoethyl)-1-naphthylacetamide is a metabolite of Naphazoline that has been seen to be a strong collector for pyrophyllite.

Upstream product

• 835-31-4 naphazoline 
• 86-87-3 naphth-1-yl acetic acid 
• 107-15-3 ethylenediamine 

Downstream Products

• 1453814-68-0 C₂₇H₃₂N₄O₂ 
• 1453814-89-5 C₂₁H₂₇N₃O₂ 
• 1453814-69-1 C₃₄H₃₄F₃N₅O₃ 
• 1453814-70-4 C₃₆H₄₀N₄O₅ 
• 1453814-71-5 C₃₆H₄₀N₄O₃ 
• 1453814-72-6 C₃₆H₃₄F₆N₄O₃ 
• 1453814-73-7 C₃₂H₃₄N₄O₃S 
• 1453814-74-8 C₃₅H₃₈N₄O₄ 
• 1453814-91-9 C₂₈H₂₉F₃N₄O₃ 
• 1453814-92-0 C₂₉H₂₇F₆N₃O₃ 
• 1453814-67-9 C₄₂H₄₂N₄O₄ 

Relevant articles and documents

Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor

VEGFR, ERK and Abl had been respectively identified as good drug targets, and their crosstalk also had been well elaborated. Multitarget drugs were more advantageous for cancer treatment, however, no inhibitors simultaneously acting on the three proteins were developed due to their structural diversities. Herein, N-(4-((2-(2-(naphthaen-1-yl)acetamido)ethyl)carbamoyl)piperidin-4-yl)-6- (trifluoromethyl)nicotinamide (NEPT, 6a) was discovered as an active scaffold against VEGFR-2, ERK-2 and Abl-1 kinases through the combination of support vector machine, similarity searching and molecular docking. NEPT and its derivatives were synthesized by convenient routine, their in vitro anti-proliferative abilities against human liver cancer cell line HepG2 were preliminarily evaluated. A representative compound 6b showed an IC50 value of 11.3 μM and induced significant HepG2 cells apoptosis. Besides, these compounds displayed better anti-proliferative abilities against K562 cells (a cell line with typical hyperactivity of the above multikinases), for example compound 6b exhibited an IC50 value of 4.5 μM. Based on hepatotoxicity case reports of Abl inhibitors, cytotoxicity of synthetic compounds against normal liver cell lines (QSG7701 and HL7702) was studied, 6b had a similar toxic effect with positive control imatinib, and most compounds showed less than 35% inhibition activities at 100 μM. Molecular docking study disclosed interactions of 6b with VEGFR-2, ERK-2 and Abl-1 kinases, respectively. Our data suggested the biological activities of 6b may derived from collaborative effects of VEGFR-2, ERK-2 and Abl-1 inhibition.