36335-89-4Relevant academic research and scientific papers
Trizaine-based dehydrative condensation reagents bearing carbon-substituents
Kitamura, Masanori,Komine, Sayaka,Kunishima, Munetaka,Yamada, Kohei
, (2020/02/22)
Herein, we report on the synthesis of alkyl-, aryl-, and alkynyl-substituted chlorotriazines and their ammonium salts, and demonstrate their utility in dehydrative condensation reactions. Although the electrophilicity of these reagents is mainly dependent on the hybridization of the carbon-substituents, it was found that bulky 2,6-dimethylphenyl group-substituted reagents resulted in the highest product yields because of a slight increase in reagent electrophilicity and/or steric hindrance favorable for desired dehydrative condensation reactions.
DEHYDRATION CONDENSATION AGENT
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Paragraph 0195; 0197; 0201; 0214-0216, (2018/09/02)
PROBLEM TO BE SOLVED: To provide a novel compound useful as a condensation agent when producing a carboxylic acid derivative, such as ester and amide, by a dehydration condensation reaction, and a dehydration condensation agent comprising the compound. SOLUTION: The present invention provides a triazine quaternary ammonium compound represented by formula (I) and a dehydration condensation agent comprising the compound [R1 is C1-4 alkyl group; R2 and R3 independently represent a substituted/unsubstituted alkyl group, a substituted/unsubstituted secondary cyclic amino group formed with a nitrogen atom bonded thereto, or the like; X1 is a substituted/unsubstituted alkoxy group or a substituted/unsubstituted aryloxy group; X2 is a substituted/unsubstituted alkyl group, a substituted/unsubstituted cycloalkyl group, or the like; Y-is a counter anion with no nucleophilicity or with low nucleophilicity]. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
