36340-59-7

Basic information

• Product Name: 4-(1,3-dioxoisoindolin-2-yl)-N-(thiazol-2-yl)benzenesulfonamide
• CAS NO: 36340-59-7
• Molecular Formula: C₁₇H₁₁N₃O₄S₂
• Molecular Weight: 385.41694
• Mol File: 36340-59-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1,3-dioxoisoindolin-2-yl)-N-(thiazol-2-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-dioxoisoindolin-2-yl)-N-(thiazol-2-yl)benzenesulfonamide(36340-59-7)
• EPA Substance Registry System: 4-(1,3-dioxoisoindolin-2-yl)-N-(thiazol-2-yl)benzenesulfonamide(36340-59-7)

Safety Data

• Hazardous Substances Data: 36340-59-7(Hazardous Substances Data)

Upstream product

• 96-50-4 2-thiazolylamine 
• 4435-59-0 4-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)-1-benzenesulfonyl chloride 
• 85-73-4 Cremothalidine 
• 85-44-9 phthalic anhydride 
• 72-14-0 Sulfathiazole 
• 520-03-6 N-phenylphthalimide 

Downstream Products

• 85-73-4 Cremothalidine 

Relevant articles and documents

Synthesis and antimycobacterial activity of some phthalimide derivatives

Structurally modified phthalimide derivatives were prepared through condensation of phthalic and tetrafluorophthalic anhydride with selected sulfonamides with variable yields. All compounds were screened for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) using a micro broth dilution technique. The fluorinated derivatives (compounds 2c, 2d, 2f and 2h) had antimycobacterium activity comparable with classical sulfonamide drugs. The minimum inhibitory concentration (MIC) of compounds 2c, 2d, 2f and 2h was greater than that of isoniazid (MIC 0.02 μg/mL) and in vitro activity was greater than that of pyrazinamide, another first line antimycobacterium drug (MIC 50-100 μg/mL). The new compounds could be considered new lead compounds in the treatment of multi-drug resistant tuberculosis.