363623-08-9

Usage

Uses

Used in Organic Synthesis:
(S)-tert-Butyl 2-((1R,2S)-1-methoxy-2-methylbut-3-en-1-yl)pyrrolidine-1-carboxylate is used as an intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structural features allow it to serve as a building block in the assembly of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (S)-tert-Butyl 2-((1R,2S)-1-methoxy-2-methylbut-3-en-1-yl)pyrrolidine-1-carboxylate is used as a key component in the development of new drugs. Its structural complexity and the presence of multiple functional groups make it a valuable candidate for the design and synthesis of novel therapeutic agents.
Used in Chemical Reaction Studies:
(S)-tert-Butyl 2-((1R,2S)-1-methoxy-2-methylbut-3-en-1-yl)pyrrolidine-1-carboxylate is also utilized in the study of chemical reactions involving pyrrolidine derivatives. Understanding how (S)-tert-Butyl 2-((1R,2S)-1-methoxy-2-methylbut-3-en-1-yl)pyrrolidine-1-carboxylate reacts under various conditions can provide insights into the reactivity of similar compounds and contribute to the advancement of synthetic methodologies.

Upstream product

• 61295-58-7 anhydrovinblastine eniminium 
• 2182-14-1 vindoline 
• 26251-91-2 18(R)-methoxycarbonylcleavamine 
• 38390-45-3 anhydrovinblastine 

Downstream Products

• 55383-37-4 desacetylvinblastine hydrazide 
• 61936-68-3 vinblastine N'b-oxide 

Relevant academic research and scientific papers

Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of cath

A HIGHLY EFFICIENT AND COMMERCIALLY IMPORTANT SYNTHESIS OF THE ANTITUMOR CATHARANTHUS ALKALOIDS VINBLASTINE AND LEUROSIDINE FROM CATHARANTHINE AND VINDOLINE

Extensive studies of various reaction parameters for the chemical coupling of catharanthine (1) and vindoline (2) followed by evaluation of highly unstable intermediates by careful reaction control have provided essentially a quantitative yield in this coupling reaction.Subsequent regioselective reduction of the resultant intermediate 3 by select NADH models affords a high yield of an enamine (5) which, without isolation, is selectively oxidized to unstable iminium intermediates 6 and 7 and the latter, again without isolation, are finally reduced to vinblastine (8, 40percent), leurosidine (10, 16percent), and 3',4'-anhydrovinblastine (4, 12percent).The entire process of five steps (1->11+2->3->5->6,7->8,10,4) can be achieved in a one-pot operation and the high overall yield of vinblastine (8) requires that each reaction must proceed in yields in excess of 80percent.