36372-62-0

Usage

Synonyms

4-Bromo-2-Amino-Propiophenone

Application

Key intermediate in the synthesis of pharmaceuticals and organic compounds

Physical state

White to off-white solid at room temperature

Solubility

Soluble in organic solvents such as ethanol and acetone

Pharmaceutical industry

Building block for the synthesis of various drugs

Chemical research and development

Employed as a reagent

Upstream product

• 591-19-5 m-Bromoaniline 
• 109-74-0 propyl cyanide 
• 36372-59-5 4-bromo-2-nitrophenyl-cyclopropane 
• 1124-14-7 1-bromo-4-cyclopropylbenzene 
• 107-12-0 propiononitrile 
• 36372-60-8 2-propionyl-5-bromonitrosobenzene 

Downstream Products

• 1089342-05-1 C₁₇H₁₆BrNO₂ 

Relevant academic research and scientific papers

Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP)

Tariquidar derivatives have been described as potent and selective ABCG2 inhibitors. However, their susceptibility to hydrolysis limits their applicability. The current study comprises the synthesis and characterization of novel tariquidar-related inhibit

Transformations of N-(2-acylaryl)benzamides and their analogs under the Camps cyclization conditions

N-(2-Acylaryl)benzamides and analogous N-substituted furan-2-, thiophene-2-, and cyclopropane-carboxamides in the systems EtONa–EtOH, EtONa–THF, and t-BuOK–t-BuOH undergo Camps cyclization to 2-aryl-, 2-hetaryl-, and 2-cyclopropylquinolin-4(1H)-ones with

Design of new reaction conditions for the Sugasawa reaction based on mechanistic insights

A process to prepare 2-propionyl-4-bromoaniline by ortho acylation of 4-bromoaniline under Sugasawa conditions was developed. Upon scale-up in a pilot plant, the process gave lower yields than in the laboratory in four out of five plant runs. Analysis of

Synthesis and antitumor activity of 20(S)-camptothecin derivatives. A-ring-substituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives

Twenty-six novel A-ring-modified 7-ethylcamptothecins (6) were synthesized by Friedlander's condensation of the chiral tricyclic ketone (5) with aminopropiophenones (4). The compounds substituted with fluorine at the 11 position showed strong cytotoxicity

Camptothecin derivatives

New campotothecin derivatives and a process for preparing same are disclosed, which are represented by the general formula: STR1 wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or an amino, hydroxyl, lower acylamino or lower alkoxy group, R3 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, nitro, amino, cyano or di(lower alkyl)amino group, R4 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, lower alkylthio, amino, cyano or di(lower alkyl)amino group, and R5 represents a hydrogen or halogen atom or a hydroxyl or lower alkoxy group, with the proviso that all of the R2, R3, R4 and R5 substituents should not be a hydrogen atom and also that if any one of the R2, R3, R4 and R5 is a hydroxyl or lower alkoxy group, all of the other three substituents should not be a hydrogen atom.