36376-47-3 Usage
Description
4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.
Uses
Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells.
Biological Activity
4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
references
[1]. lim hd, van rijn rm, ling p, et al. evaluation of histamine h1-, h2-, and h3-receptor ligands at the human histamine h4 receptor: identification of 4-methylhistamine as the first potent and selective h4 receptor agonist. journal of pharmacology and experimental therapeutics, 2005, 314(3): 1310-1321.[2]. ahmad sf, ansari ma, zoheir kma, et al. regulation of tnf-α and nf-κb activation through the jak/stat signaling pathway downstream of histamine 4 receptor in a rat model of lps-induced joint inflammation. immunobiology, 2015, 220(7): 889-898.
Check Digit Verification of cas no
The CAS Registry Mumber 36376-47-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,3,7 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 36376-47:
(7*3)+(6*6)+(5*3)+(4*7)+(3*6)+(2*4)+(1*7)=133
133 % 10 = 3
So 36376-47-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H11N3.2ClH/c1-5-6(2-3-7)9-4-8-5;;/h4H,2-3,7H2,1H3,(H,8,9);2*1H
