364-75-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-5-iodonitrobenzene is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new molecules with improved properties, such as enhanced bioavailability and target specificity.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoro-5-iodonitrobenzene serves as an intermediate in the production of agrochemicals, potentially leading to the creation of more effective and targeted pesticides or herbicides.
Used in Organic Chemistry Research:
2-Fluoro-5-iodonitrobenzene is utilized as a building block in organic chemistry for the synthesis of complex organic compounds, taking advantage of its unique structural features to explore novel chemical reactions and mechanisms.
Used in Material Science:
2-Fluoro-5-iodonitrobenzene is also employed in material science for the development of new materials with specific properties, such as improved conductivity or magnetism, by incorporating its fluoro and iodo groups into the material's structure.

InChI:InChI=1/C6H3FINO2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 364-76-1 4-Fluoro-3-nitroaniline 
• 1000339-51-4 3-fluoro-2-nitro-benzoic acid 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 52692-09-8 4-iodo-2-nitroanisole 
• 20691-72-9 4-iodo-2-nitroaniline 
• 79291-47-7 3-(4-Iodo-2-nitroanilino)-1-methylpyrazole-4-carbonitrile 
• 594862-23-4 N-benzyl-4-iodo-2-nitroaniline 
• 866686-98-8 3-chloro-5-(4-fluoro-3-nitrophenylethynyl)-pyridine 
• 1160926-61-3 1-(4-iodo-2-nitrophenyl)-4-phenyl-1H-1,2,3-triazole 
• 1246566-57-3 1-dodecylthio-4-iodo-2-nitrobenzene 
• 1430727-54-0 N-(5-(2-amino-4-iodophenylamino)-2',4'-difluorobiphenyl-3-yl)acetamide 
• 1430727-56-2 N-(2',4'-difluoro-5-(5-iodo-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide 
• 1430727-57-3 N-(2',4'-difluoro-5-(5-((trimethylsilyl)ethynyl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)acetamide 
• 1430727-59-5 N-(5-(5-ethynyl-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)-acetamide 
• 1430723-47-9 N-(2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide 
• 1430727-61-9 2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine 
• 1430723-48-0 N-(2',4'-difluoro-5-(5-(2-methyl-2H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)methanesulfonamide 

Relevant academic research and scientific papers

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Method for synthesizing m-iodonitrobenzene compound

Provided is a method for synthesizing m-iodonitrobenzene; in the presence of oxygen gas, a palladium catalyst, a copper additive, a bismuth reagent and potassium phosphate, an o-nitrobenzoic acid compound and metal iodide are subjected to a substitution reaction in an organic solvent to form a corresponding m-iodonitrobenzene compound, wherein a metal in the metal iodide is an alkali metal or an alkaline earth metal. The method has obvious advantages of cheap and easily obtained reaction raw materials (including o-nitrobenzoic acid and MI), small amount of the metal catalyst, minimum environmental pollution with oxygen gas as an oxidant, good tolerance on various functional groups on an aromatic ring and the like. The method can be widely applied in the fields of synthesis of drugs, materials, natural products and the like in industrial and academic circles.

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.

N-halosuccinimide/BF3-H2O, efficient electrophilic halogenating systems for aromatics

N-Halosuccinimides (NXS, 1) are efficiently activated in trifluoromethanesulfonic acid and BF3-H2O, allowing the halogenations of deactivated aromatics. Because BF3-H2O is more economic, easy to prepare, nonoxidizing, and offers sufficiently high acidity (-H0 ≈ 12, only slightly lower than that of trifluoromethanesulfonic acid), an efficient new electrophilic reagent combination of NXS/BF3-H2O has been developed. DFT calculations at the B3LYP/6-311++G**//B3LYP/6-31G* level suggest that protonated N-halosuccinimides undergo further protosolvation at higher acidities to reactive superelectrophilic species capable either in the transfer of X+ from the protonated forms of NXS to the aromatic substrate or in forming a highly reactive and solvated X+ which would readily react with the aromatic substrates. Structural aspects of the BF 3-H2O complex have also been investigated.