36401-95-3Relevant academic research and scientific papers
METHOD FOR PRODUCING OLEFIN MULTIMER
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Paragraph 0197-0198, (2021/10/02)
PROBLEM TO BE SOLVED: To solve the problem in which: the amount of by-products of polyolefin tends to increase when the reaction temperature is increased in the case where the olefin multimerization reaction is caused to occur in the presence of a catalyst including a chromium compound. SOLUTION: In a specific reaction temperature range, in the presence of a catalyst for olefin multimerization including a chromium compound (A), a specific compound (B), and a compound such as an organic metal compound (C), the olefin multimerization reaction is caused to occur at a relatively high temperature, so that olefin multimers can be produced while reducing by-products of olefin polymers. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Synthesis, characterization, and anti-amoebic screening of core-modified 5,20-bis{2-{[(alkyl)(alkyl′)amino]methyl}ferrocen-1-yl}-10,15-diphenyl-21, 23-dithiaporphyrin (=1,1″-(10,15-diphenyl-21,23-dithiaporphine-5,20-diyl) bis[2-{[(alkyl)(alkyl′)amino]methyl}ferrocene]) derivatives
Bhat, Abdul R.,Bhat, Asif I.,Athar, Fareeda,Azam, Amir
experimental part, p. 1644 - 1656 (2009/10/16)
The synthesis of the first bis-ferrocenyl-substituted core-modified porphyrins, 5,20-bis{2-{[(alkyl)-(alkyl′)amino]methyl}ferrocen-1-yl}-10, 15-diphenyl-21,23-dithiaporphyrin derivatives 6a - 6j, via a multistep route is reported (Schemes 1, 2, and 4). The synthesis was carried out through acid-catalyzed (BF3 ? Et2O) condensation of 1,1″- [thiophene-2,5-diylbis(hydroxymethyl)]bis[2-{[(alkyl)(alkyl′)amino]methyl} ferrocenes] 4a - 4j with 2,2′-[thiophene-2,5-diylbis(phenylmethylene)] bis[1H-pyrrole] (5b) in presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (=4,5-dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile; DDQ). Characterization of the compounds was done at each step by means of various spectroscopic techniques. The final compounds were screened for in vitro anti-amoebic activity against the strain HM1:IMSS of E. histolytica (Table 2).
A New Route to Sila- and Phosphaheterocycles: Nucleophilic Aminomethylation
Karsch, Hans H.,Schreiber, Kai-A.,Herker, Martin
, p. 1777 - 1786 (2007/10/03)
The aminals tetramethylmethylenediamine (TMMDA) 1a, dicyclohexyldimethylmethylenediamine (CMMDA) 1b, and diisopropyldimethylmethylenediamine (IMMDA) 1c are doubly metalated by LitBu to give LiCH2N(R)CH2N(R)CH2Li , which precipitate out of pentane as highly pyrophoric substances.Deuteration confirms N-methyl metalation exclusively.A series of aminomethylation reactions were performed by means of the doubly lithiated aminals 2a-c.The reactions of 2a-c with monochlorosilanes yield the silylated species R'3SiCH2N(R)CH2N(R)CH2SiR'3 (3a: R' = Me, R = Me; 3b: R' = Me, R = Cy; 3c: R' = Me, R = iPr; 4: R' = Ph, R = Me, see Scheme 2).The use of dichlorosilanes leads to six-membered heterocycles 6a-6d. 6a is transferred into a mono quaternary ammonium salt 7 by methylation with MeI.The spirocycle 8 is obtained from SiCl4 and two equivalents of 2a.Similarly, several substituted 1,3-diaza-5-phosphacyclohexanes 9a-e (R1 = Me, Ph, NPh2, NCy2, see Scheme 3) are synthesized by the reaction of dichlorophosphanes R1PCl2 with 2a and 2b, respectively.Oxidation of 9d with sulfur yields 12a, which is characterized by X-ray structure determination. - Keywords: Lithiation; Aminomethylation; Nitrogen heterocycles; Diazasilaheterocycles; Diazaphosphaheterocycles
