364045-18-1

Upstream product

• 15190-10-0 morpholin-4-yl-phenyl-acetonitrile 
• 128562-58-3 N-methyl-N-methoxy-3-bromopropionamide 

Downstream Products

• 127931-48-0 1-(naphthalen-1-yl)-4-phenylbutane-1,4-dione 
• 77588-52-4 1-Phenyl-1,4-octanedione 

Relevant academic research and scientific papers

N-Methoxy-N-methyl-3-bromopropionamide: A new three carbon homologating agent for the synthesis of unsymmetrical 1,4-diketones

A synthetic route based on a three carbon homologation of an α-aminonitrile was developed for the synthesis of unsymmetrical 1,4-diketones. The key steps were the alkylation of various aryl and heteroaryl α-aminonitriles with N-methoxy-N-methyl-3-bromopropionamide followed by the addition of a Grignard reagent to the alkylated product and then subsequent hydrolysis.