128562-58-3

Upstream product

• 590-92-1 3-Bromopropionic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 15486-96-1 3-Bromopropionyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 276238-63-2 2-benzenesulfonyl-pentanedioic acid bis-(methoxy-methyl-amide) 
• 3400-24-6 N-methylheptanamide 
• 364045-21-6 4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide 
• 364045-20-5 4-(3-chlorophenyl)-4-cyano-4-morpholino-N-methoxy-N-methylbutyramide 
• 244168-29-4 N-methoxy-N-methyl-4-oxo-4-phenylbutanamide 
• 364045-18-1 4-cyano-4-morpholino-4-phenyl-N-methoxy-N-methylbutyramide 
• 364045-22-7 4-cyano-4-(4-methoxyphenyl)-4-morpholino-N-methoxy-N-methylbutyramide 
• 405212-31-9 3-(benzenesulfonyl-methyl-amino)-N-methoxy-N-methyl-propionamide 
• 405212-29-5 3-dibenzylamino-N-methoxy-N-methyl-propionamide 
• 1206600-58-9 N-methoxy-N-methyl-3-[3-methyl-2-oxo-4-(3-trifluoromethoxy-phenyl)-piperazin-1-yl]-propionamide 
• 1318771-03-7 3-(benzylseleno)-N-methoxy-N-methylpropanamide 
• 1474048-92-4 N-methoxy-N-methyl-3-(phenylselanyl)propanamide 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF (+)- AND (-)-NORSECURININE

(-)-Norsecurinine (1a) has been prepared in a stereospecific fashion beginning with the acetylenic oxazole 18.Diels-Alder cyclization of 18 afforded the furanoketone 19, which was transformed in five steps to the butenolide mesylate 24.Transannular alkyla

Chemoselective Dieckmann-like condensations using N-methoxy-N-methylamides

The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.

Weinreb Amide based building block for convenient access to vinyl ketones

A new strategy for the synthesis of vinyl ketones has been achieved. Hitherto unknown and easily accessible, β-phenylseleno-N-methoxy-N- methylpropanamide, obtained through two simple reactions, served as a building block for convenient access to vinyl ketones. The N-methoxy-N-methyl amide moiety ensured no overaddition of the Grignard reagent and, hence, the excellent formation of β-phenylseleno ketones; oxidative work-up with hydrogen peroxide provided ready access to the vinyl ketones with concomitant loss of phenylselanol. Georg Thieme Verlag Stuttgart · New York.

PHARMACEUTICAL COMPOUNDS

The present invention relates to inhibitors of serotonin and/or norepinephrine reuptake and specifically provides compounds of formula (I): wherein A is selected from -O- and -S-; X is selected from C1-C8 alkyl, C2-C8 alkenyl, and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from phenyl, pyrrolidinyl, piperidinyl, morpholinyl, halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, -CF3, -CN and -CONH2; Y is selected from (a), (b), (c), (d), (e), (f) where R3, R4and R5 are independently selected from hydrogen, halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; R6 and R7 are independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; R8 is selected from chloro, bromo, iodo, C1-C4alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; R1 and R2 are each independently hydrogen or C1-C4 alkyl; or pharmaceutically acceptable salts thereof; or compositions thereof and methods of using the same.

PROPANAMINE DERIVATIVES AS SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS

There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4 alkyl, and C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, -CF3, -CN and -CONH2; Y is selected from dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, and thienopyridyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; Z is selected from H, OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof.

Simple synthetic equivalents for the β-(N,N-disubstituted)ethylamino acyl cation synthon and their applications

Various N,N-disubstituted-β-amino-N-methoxy-N-methylpropanamides 3a-i were prepared which served as an excellent β-aminoacyl cation equivalents. These were used to prepare β-amino ketones 1, pharmacologically active tertiary 1-(3,3-diarylpropyl)amines 7a-c, and the interesting C-glycoside 8.

Bis-heteroannulation. 15. Enantiospecific syntheses of (+)and (-)-norsecurinine

(-)-Norsecurinine (2a) has been prepared in a stereospecific fashion with the acetylenic oxazole 39 as the starting material. Diels-Alder cyclization of 39 afforded the furano ketone 45 that was transformed in five steps to the butenolide mesylate 52. Tra

A CONVENIENT METHOD FOR THE PREPARATION OF N-METHOXYAMIDES

A variety of N-methoxyamides is easily prepared from carboxylic acids and N,O-dimethylhydroxylamine hydrochloride in the presence of triphenylphosphine and carbon tetrabromide.