364048-15-7Relevant academic research and scientific papers
A library approach to the generation of bisubstrate analogue sulfotransferase inhibitors
Armstrong, Joshua I.,Ge, Xue,Verdugo, Dawn E.,Winans, Katharine A.,Leary, Julie A.,Bertozzi, Carolyn R.
, p. 2657 - 2659 (2007/10/03)
(Equation presented) A library of potential bisubstrate analogue inhibitors (1) targeting sulfotransferase enzymes was generated by the chemoselective ligation of the PAPS mimic 2 with a panel of 447 aldehydes. Preliminary screening has identified compounds that inhibit estrogen sulfotransferase (EST), an enzyme relevant to breast cancer.
