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**2-Butanone, 4-(1H-pyrrol-2-yl)- (9CI)** is a product of the conjugate addition of pyrrole to an α,β-unsaturated ketone, specifically forming a 2-substituted pyrrole derivative with a 3-oxobutyl side chain. 2-Butanone, 4-(1H-pyrrol-2-yl)- (9CI) can be synthesized efficiently using iodine or hafnium chloride as catalysts under mild conditions, demonstrating its accessibility in organic synthesis. The reaction typically yields monoalkylated products when stoichiometric amounts are used, though excess enones may lead to further substitution patterns. (Returned based on the provided literature abstracts.)

364064-30-2

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364064-30-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 364064-30-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,4,0,6 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 364064-30:
(8*3)+(7*6)+(6*4)+(5*0)+(4*6)+(3*4)+(2*3)+(1*0)=132
132 % 10 = 2
So 364064-30-2 is a valid CAS Registry Number.

364064-30-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3-oxobutyl)pyrrole

1.2 Other means of identification

Product number -
Other names 4-(2-pyrrolyl)butan-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:364064-30-2 SDS

364064-30-2Relevant articles and documents

Iodine-catalyzed efficient conjugate addition of pyrroles to α,β-unsaturated ketones

Das, Biswanath,Chowdhury, Nikhil,Damodar, Kongara

, p. 2867 - 2870 (2007)

Iodine was used as a catalyst for the conjugate addition of pyrroles to α,β-unsaturated ketones at room temperature. Mono- and dialkylated products were obtained by using equimolar amounts of the reactants. However, the use of excess enones afforded only

Remarkable Lewis acid catalytic performance of the scandium trimesate metal organic framework MIL-100(Sc) for C-C and C=N bond-forming reactions

Mitchell, Laura,Gonzalez-Santiago, Berenice,Mowat, John P. S.,Gunn, Mary E.,Williamson, Patrick,Acerbi, Nadia,Clarke, Matthew L.,Wright, Paul A.

, p. 606 - 617 (2013/05/08)

The porous metal organic frameworks scandium trimesate MIL-100(Sc), scandium terephthalates MIL-101(Sc), MIL-88B(Sc) and MIL-68(Sc), scandium 4,4′-biphenyl-dicarboxylate MIL-88D(Sc) and the scandium 3,3′,5,5-azobenzene-tetracarboxylate socMOF(Sc) have bee

Ruthenium-catalyzed functionalization of pyrroles and indoles with propargyl alcohols

Thies, Nora,Hrib, Cristian G.,Haak, Edgar

supporting information; experimental part, p. 6302 - 6308 (2012/06/18)

Several ruthenium-catalyzed atom-economic transformations of propargyl alcohols with pyrroles or indoles leading to alkylated, propargylated, or annulated heteroaromatics are reported. The mechanistically distinct reactions are catalyzed by a single ruthenium(0) complex containing a redox-coupled dienone ligand. The mode of activation regarding the propargyl alcohols determines the reaction pathway and depends on the alcohols' substitution pattern. Secondary substrates form alkenyl complexes by a 1,2-hydrogen shift, whereas the transformation of tertiary substrates involves allenylidene intermediates. 1-Vinyl propargyl alcohols are converted by a cascade allylation/cyclization sequence. The environmentally benign processes are of broad scope and allow the selective synthesis of highly functionalized pyrroles and indoles generating water as the only waste product. Copyright

Synthesis and application of modified silica sulfuric acid as a solid acid heterogeneous catalyst in Michael addition reactions

Zolfigol, Mohammad Ali,Veisi, Hojat,Mohanazadeh, Farajollah,Sedrpoushan, Alireza

experimental part, p. 977 - 986 (2011/09/16)

Figure represented. Modified silica sulfuric acid (MSSA) as a new type of silica sulfuric acid was prepared and effectively used in the conjugate addition of indole, pyrrole, and thiols with Michael acceptors under mild conditions at room temperature. Als

Iron salt-cataltzed multipoint alkylation of pyrrole with vinyl ketones

Kawatsura, Motoi,Fujiwara, Masamune,Uehara, Hiroyuki,Nomura, Shun,Hayase, Shuichi,Itoh, Toshiyuki

, p. 794 - 795 (2008/12/21)

Pyrrole reacted with vinyl ketones in the presence of 3 mol % of iron(II) tetrafluoroborate or alumina-supported iron(III) perchlorate to give multipoint-alkylated products in good yield. Most notably, 4,5-dialkylated 2-acetylpyrrole was obtained in good

Asymmetric Friedel-Crafts alkylation of pyrroles with nitroalkenes using a dinuclear zinc catalyst

Trost, Barry M.,Mueller, Christoph

, p. 2438 - 2439 (2008/09/19)

The catalytic enantioselective and atom economic Friedel-Crafts alkylation of pyrroles with nitroalkenes under mild reaction conditions using a dinuclear zinc catalyst is reported. The versatility of the reaction is demonstrated by the conversion of a number of differentially substituted nitroalkenes with differentially substituted pyrroles. Tandem addition reactions to form 2,5-disubstituted pyrroles are also demsonstrated. All pyrrole alkylations have been carried out without using N-protecting groups, which also enhances the efficiency by which substituted pyrroles may be synthesized. The reactions result in good yields and excellent enantioselectivities. Copyright

Catalytic conjugate addition of heterocyclic compounds to α,β-unsaturated carbonyl compounds by hafnium salts and scandium salts

Kawatsura, Motoi,Aburatani, Sachiko,Uenishi, Junichi

, p. 4172 - 4177 (2008/01/08)

The hafnium chloride (HfCl4) and scandium chloride (ScCl3) catalyzed conjugate additions of heterocyclic compounds, such as indoles, pyrrole, pyrazole, and imidazole, have been demonstrated. Hafnium chloride effectively catalyzed the

Hafnium chloride catalyzed conjugate addition of pyrrole, pyrazole and imidazole to α,β-unsaturated ketones

Aburatani, Sachiko,Kawatsura, Motoi,Uenishi, Jun'ichi

, p. 189 - 196 (2008/02/02)

Pyrrole, pyrazole and imidazole undergo conjugate addition with α,β-unsaturated ketones in the presence of a catalytic amount of hafnium chloride at room temperature. Although the reaction of pyrrole gave 2,5-substituted C-adduct mainly, those of pyrazole

Bismuth trichloride-catalyzed C-alkylation of pyrroles with electron-deficient olefins

Zhan, Zhuang-Ping,Yu, Jing-Liang,Yang, Wen-Zhen

, p. 1373 - 1382 (2007/10/03)

The BiCl3-catalyzed reaction of pyrroles with electron-deficient olefins generated the corresponding Michael adducts in high yields. Copyright Taylor & Francis Group, LLC.

Efficient Friedel-crafts alkylation of indoles and pyrrole with enones and nitroalkene in water

Azizi, Najmedin,Arynasab, Fezzeh,Saidi, Mohammad R.

, p. 4275 - 4277 (2008/09/18)

An operationally simple and entirely green protocol for heteropoly acid catalyst conjugate addition of indoles and pyrrole to unsaturated carbonyl compounds and nitro-alkene in water was investigated. It is important that the products arising from 1,2-add

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