364078-26-2Relevant articles and documents
Nicotinamide N-oxides as CXCR2 antagonists
Cutshall, Neil S,Ursino, Rocky,Kucera, Kristin A.,Latham, John,Ihle, Nathan C.
, p. 1951 - 1954 (2001)
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-α-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.