36418-96-9Relevant articles and documents
8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity
Li, Dajie,Zhao, Baoping,Sim, Sai-Peng,Li, Tsai-Kun,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.
, p. 3795 - 3805 (2007/10/03)
Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit topoisomerase I-targeting activity. Structure-activity studies were performed to examine the influence of saturation at the 11,12-positions of several substituted 8,9-methylenedioxybenzo[i]phenanthridines. The activities of these dihydro analogues were compared to those of their unsaturated analogues. In addition, the influence of varying substituents at the 2- and 3-positions within the A-ring of these 8,9-methylenedioxybenzo[i]phenanthridines on their relative potency as topoisomerase I-targeting agents and cell proliferation as determined using the MTT assay was investigated. 2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine and its 11,12-dihydro derivative were among the more potent analogues evaluated with regard to topoisomerase I-targeting activity and cytotoxicity.
Some Studies on the Use of 2-Bromoethyl and 2-Iodoethyl Ester Blocking Groups in Peptide Synthesis: Samarium Diiodide-Mediated Deprotection
Pearson, Anthony J.,Lee, Kieseung
, p. 2257 - 2260 (2007/10/02)
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