127399-74-0

Upstream product

• 127399-73-9 5-(benzyloxy)-6-methoxy-1-methyleneindan 
• 127399-72-8 5-(benzyloxy)-6-methoxy-1-indanone 
• 127399-78-4 5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one 
• 159749-96-9 <3-(Benzyloxy)-4-methoxyphenyl>propionic acid benzyl ester 
• 653580-54-2 3-(3-benzyloxy-4-methoxyphenyl)propionic acid chloride 
• 1135-15-5 dihydroisoferulic acid 
• 537-73-5 isoferulic acid 
• 36418-96-9 3-<3-(Benzyloxy)-4-methoxyphenyl>propionic acid 

Downstream Products

• 106824-44-6 trans-8-(benzyloxy)-9-methoxy-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline 
• 106824-41-3 trans-8-(benzyloxy)-9-methoxy-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3(2H)-one 
• 106824-38-8 8-(benzyloxy)-9-methoxy-1,4,5,6-tetrahydrobenzoquinolin-3(2H)-one 

Relevant academic research and scientific papers

8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity

Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit topoisomerase I-targeting activity. Structure-activity studies were performed to examine the influence of saturation at the 11,12-positions of several substituted 8,9-methylenedioxybenzo[i]phenanthridines. The activities of these dihydro analogues were compared to those of their unsaturated analogues. In addition, the influence of varying substituents at the 2- and 3-positions within the A-ring of these 8,9-methylenedioxybenzo[i]phenanthridines on their relative potency as topoisomerase I-targeting agents and cell proliferation as determined using the MTT assay was investigated. 2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine and its 11,12-dihydro derivative were among the more potent analogues evaluated with regard to topoisomerase I-targeting activity and cytotoxicity.

Monomethyl Ether Derivatives of 7,8-Dihydroxy- and 8,9-Dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines as Possible Products of Metabolism by Catechol-O-methyltransferase

In order to facilitate identification of possible metabolites arising from in vitro action of catechol-O-methyltransferase upon 7,8-dihydroxy- and 8,9-dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines (11, 12), all four possible monomethyl ether derivatives have been synthesized.Incubation of 11 and 12 with the enzyme revealed that the 8,9-dihydroxy positional isomer 12 (which contains the dopamine moiety held in the β conformation) but not the 7,8-dihydroxy isomer 11 (which holds the dopamine moiety in the α conformation) was a substrate for theenzyme.The sole detectable product of 12 was 8-hydroxy-9-methoxy derivative 15 in which the "meta" hydroxy group of the dopamine moiety is etherified.