364337-02-0Relevant academic research and scientific papers
Synthesis of 2′-modified nucleotides
Gallo, Mariana,Torres, Hector,Iribarren, Adolfo
, p. 727 - 729 (2000)
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2′-OH which is essential for the activity of these molecules. Our final goal is to generate a
2′-C-Methyluridine phosphoramidite: A new building block for the preparation of RNA analogues carrying the 2′-hydroxyl group
Gallo, Mariana,Monteagudo, Edith,Cicero, Daniel O,Torres, Héctor N,Iribarren, Adolfo M
, p. 5707 - 5713 (2007/10/03)
A new stereoselective synthesis of 2′-C-methyluridine was carried out. The preparation of the corresponding protected phosphoramidite suitable for the automated synthesis of oligonucleotides, including the regioselective protection of the 2′-hydroxyl grou
