364337-06-4

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 364337-05-3 2'-C-methyl-2'-O-(tetrahydropyran-2-yl)uridine 
• 364337-02-0 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-p-toluenesulfonylmethyleneuridine 
• 159534-54-0 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-C-β-methyluridine 
• 102789-14-0 1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-pyrimidine-2,4(1H,3H)-dione 
• 110-87-2 3,4-dihydro-2H-pyran 
• 364337-04-2 3',5'-di-O-acetyl-2'-O-tetrahydropyranyl-2'-C-methyluridine 
• 364337-03-1 3',5'-di-O-acetyl-2'-C-methyluridine 
• 102789-15-1 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-hydroxymethyleneuridine 
• 31448-54-1 2'-C-methyluridine 

Relevant academic research and scientific papers

2′-C-Methyluridine phosphoramidite: A new building block for the preparation of RNA analogues carrying the 2′-hydroxyl group

A new stereoselective synthesis of 2′-C-methyluridine was carried out. The preparation of the corresponding protected phosphoramidite suitable for the automated synthesis of oligonucleotides, including the regioselective protection of the 2′-hydroxyl grou

Synthesis of 2′-modified nucleotides

We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2′-OH which is essential for the activity of these molecules. Our final goal is to generate a