364356-34-3

Upstream product

• 126533-76-4 ethyl 2-(N-phenylamino)thiazole-4-carboxylate 
• 103-85-5 monophenylthiourea 

Downstream Products

• 364356-36-5 3-({[2-(methyl-phenyl-amino)-thiazole-4-carbonyl]-amino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1036895-65-4 2-(methyl-phenyl-amino)-thiazole-4-carbonyl chloride 

Relevant academic research and scientific papers

Discovery of 2-aminothiazole-4-carboxamides, a novel class of muscarinic M3 selective antagonists, through solution-phase parallel synthesis

Synthesis and structure-activity relationship of a new class of muscarinic M3 selective antagonists were described. In the course of searching for a muscarinic M3 antagonist with a structure distinct from those of the 2-(4,4-difluorocyclopentyl)-2-phenylacetamide derivatives, we identified a thiazole-4-carboxamide derivative (1) as a lead compound in our in-house chemical collection. Since this compound (1) showed relatively low binding affinity (K1 = 140 nM) for M3 receptors in the human binding assays, we tried to improve its potency and selectivity for M 3 over M1 and M2 receptors by derivatization of 1 through a combinatorial approach. A solution-phase parallel synthesis effectively contributed to the optimization of each segment of 1. Thus, we have identified a cyclooctenylmethyl derivative (3e) and a cyclononenylmethyl derivative (3f) as representative M3 selective antagonists in this class.

Thiazole derivatives of benzoic and phenylalkanoic acids

Thiazole derivatives represented by the general formula: STR1 wherein A is oxygen, sulfur, imino, or NR3, wherein R3 is C1-5 alkyl, C2-5 alkenyl, C3-5 alkynyl, C3