36476-87-6

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzhydrylazetidine-3-carboxylic acid is used as a synthetic intermediate for the development of polypeptide-based drugs. Its role in the synthesis process is crucial, as it helps in the formation of complex polypeptide structures that can be tailored for specific therapeutic applications.
Used in Research and Development:
In the field of research and development, 1-Benzhydrylazetidine-3-carboxylic acid is used as a key component in the synthesis of novel polypeptides. This allows scientists to explore new avenues in drug discovery and the development of bioactive molecules with potential applications in various industries, such as pharmaceuticals, agriculture, and materials science.
Used in Material Science:
1-Benzhydrylazetidine-3-carboxylic acid can also be utilized in the development of advanced materials, such as polymers and coatings, that incorporate polypeptide sequences. These materials can exhibit unique properties, such as enhanced biocompatibility, biodegradability, and responsiveness to environmental stimuli, making them suitable for a range of applications, from medical devices to environmentally friendly products.

InChI:InChI=1/C17H17NO2/c19-17(20)15-11-18(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-16H,11-12H2,(H,19,20)

Upstream product

• 36476-86-5 1-(1,1-diphenylmethyl)azetidine-3-carbonitrile 
• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 53871-06-0 1-(diphenylmethyl)-3-methoxycarbonylazetidine 

Downstream Products

• 91189-21-8 1-(diphenylmethyl)-N-ethyl-3-azetidinecarboxamide 
• 91196-84-8 1-benzhydryl-N-methylazetidinecarboxylic-3-carboxamide 
• 1025712-89-3 1-benzhydrylazetidine-3-carbonylchloride hydrochloride 
• 1025712-92-8 6-(1-benzhydrylazetidin-3-yl)-1-tert-butyl-3-methyl-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one 
• 36476-78-5 3-azetidinecarboxylic acid 
• 928038-42-0 3-(Azetidin-1-ylmethyl)-1-benzhydrylazetidine 
• 53871-06-0 1-(diphenylmethyl)-3-methoxycarbonylazetidine 
• 72351-36-1 1-diphenylmethyl-3-hydroxymethylazetidine 
• 359402-66-7 1-diphenylmethyl-N-methoxy-N-methylazetidine-3-carboxamide 
• 1009368-02-8 N'-acetyl-1-benzhydrylazetidine-3-carbohydrazide 
• 928038-41-9 3-(azetidin-1-ylcarbonyl)-1-benzhydrylazetidine 
• 1009368-03-9 2-(1-benzhydrylazetidin-3-yl)-5-methyl-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Method for synthesizing azetidine -3 - formic acid

The invention relates to the field of organic synthesis and particularly relates to a synthetic method of azetidine-3-formic acid. The synthetic method comprises the following steps of adopting 2,2-bis(hydroxymethyl)malonic acid-1,3-diethyl ester to react with benzhydrylamine after protection of methylsulfonyl chloride, and then by decarboxylation and diphenylmethyl-removing protection, obtaininga final product, namely the azetidine-3-formic acid. The synthetic method has the advantages that the 2,2-bis(hydroxymethyl)malonic acid-1,3-diethyl ester is adopted as a raw material, and is cheap and easy to obtain; compared with the original synthesis route, the cost of the whole synthesis route is reduced by 30% or more, and a highly-toxic substance (sodium cyanide) is not adopted, so that theindustrial production prospect is great.

PROCESS FOR THE PREPARATION OF 2-(3-(FLUOROMETHYL)AZETIDIN-1-YL)ETHAN-1-OL

Methods of making 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol 9, an intermediate useful for the synthesis of estrogen receptor modulating compounds are described.

AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Disclosed is a compound having a strong affinity to serotonin-4 receptors, which is useful as an enterokinesis-promoting agent or a digestive tract function-improving agent. Specifically, disclosed is a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. [In Formula (1), Ar represents a group represented by Formula (Ar-1) or Formula (Ar-2).]

PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE

A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen.

NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)

A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.]

Process for preparing phenoxypyridine derivatives

A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc.; R2, R3, R4 and R5 may be the same or different and each represents hydrogen or fluorine; and R6 represents hydrogen or fluorine.

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula (I) wherein A is formula (II), formula (III) or formula (IV), and B is formula (V), formula (VI), or formula (VII), can be used in a variety of applications including use as antibacterial agents.

ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES

Compounds of formula (I) wherein: A is Formula (II), Formula (III), or Formula (IV) and B is Formula (V), Formula (VI), or Formula (VII), can be used in a variety of applications including use as antibacterial agents.

Azetidine derivatives, their preparation and pharmaceutical compositions containing them

Compounds of formula: in which R represents a CR1R2, C═C(R5)SO2R6 or C═C(R7)SO2alk radical, their preparation and the pharmaceutical compositions containing them.

1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxyic acids having antimicrobial activity have been prepared.