364765-21-9Relevant academic research and scientific papers
Bifunctional phosphine ligand-enabled gold-catalyzed direct cycloisomerization of alkynyl ketones to 2,5-disubstituted furans
Hu, Xiaojun,Zhou, Bingwei,Jin, Hongwei,Liu, Yunkui,Zhang, Liming
supporting information, p. 7297 - 7300 (2020/07/14)
An efficient synthesis of 2,5-disubstituted furans directly from alkynyl ketones has been developed via tandem gold(i)-catalyzed isomerization of alkynyl ketones to allenyl ketones and cycloisomerization. The key to the success of this chemistry is the use of a biphenyl-2-ylphosphine ligand featuring a critical remote tertiary amino group.
Facile synthesis of diiodinated dihydronaphthalenes and naphthalenes via iodine mediated electrophilic cyclization
Yang, Fan,Jin, Tienan,Bao, Ming,Yamamoto, Yoshinori
supporting information; experimental part, p. 4013 - 4015 (2011/04/27)
A facile, efficient, and general synthetic method for a wide range of 2,3-diiodinated 1,4-dihydrothiophenes and naphthalenes has been developed via the electrophilic iodocyclization of various aryl propargyl alcohols. The resulting product 2p can be used
Electrophilic carbocyclization of aryl propargylic alcohols: A facile synthesis of diiodinated carbocycles and heterocycles
Zhu, Hai-Tao,Ji, Ke-Gong,Yang, Fang,Wang, Li-Jing,Zhao, Shu-Chun,Ali, Shaukat,Liu, Xue-Yuan,Liang, Yong-Min
supporting information; experimental part, p. 684 - 687 (2011/05/03)
Diiodinated carbocycles and oxygen heterocycles can be readily synthesized by electrophilic carbocyclization of aryl propargylic alcohols in moderate to good yields under mild conditions. The resulting diiodide can be further exploited by subsequent oxidi
Palladium-catalyzed tandem dimerization and cyclization of acetylenic ketones: A convenient method for 3,3′-bifurans using PdCl2(PPh3)2
Jeevanandam,Narkunan,Ling
, p. 6014 - 6020 (2007/10/03)
Alkynones undergo tandem dimerization and cyclization in the presence of PdCl2(PPh3)2 and triethylamine in tetrahydrofuran at room temperature to give 3,3′-bifurans predominantly. Other palladium catalysts while under similar conditions, by rearrangement, lead to 2,5-disubstituted furans. This distinguished property of PdCl2(PPh3)2 has been attributed to the involvement of hydridopalladium halide. This method provides a simpler route to a variety of furans and a regioselective synthesis of polysubstituted 3,3′-bifurans using easily accessible acetylenic ketones.
