364793-54-4

Basic information

• Product Name: 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE
• Synonyms: 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE ;6-Bromo-4-chloro-quinoline-3-car;3-Quinolinecarbonitrile, 6-broMo-4-chloro-;6-bromo-4-chloro-3-Quinolinecarbonitrile
• CAS NO: 364793-54-4
• Molecular Formula: C₁₀H₄BrClN₂
• Molecular Weight: 267.50916
• Mol File: 364793-54-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 401.866 °C at 760 mmHg
• Flash Point: 196.842 °C
• Appearance: /
• Density: 1.76 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.711
• PKA: -0.52±0.27(Predicted)
• CAS DataBase Reference: 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE(364793-54-4)
• EPA Substance Registry System: 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE(364793-54-4)

Safety Data

• Hazardous Substances Data: 364793-54-4(Hazardous Substances Data)

Usage

General Description

6-Bromo-4-chloro-quinoline-3-carbonitrile is a chemical compound with the molecular formula C10H4BrClN2. It is a heterocyclic compound containing a quinoline ring with bromine and chlorine substituents, as well as a cyanide functional group. 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE is often used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. It is known for its diverse range of applications, including its use as a building block in the manufacturing of drugs and other fine chemicals. It is also known to possess antimicrobial and antifungal properties, making it a valuable compound in the development of new pharmaceutical products.

InChI:InChI=1/C10H4BrClN2/c11-7-1-2-9-8(3-7)10(12)6(4-13)5-14-9/h1-3,5H

Upstream product

• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 106-40-1 4-bromo-aniline 
• 59747-00-1 ethyl 3-((4-bromophenyl)amino)-2-cyanoacrylate 
• 58286-26-3 ethyl (Z)-3-[(4-bromophenyl)amino]-2-cyanoprop-2-enoate 
• 364793-52-2 6-bromo-4-oxo-1,4-dihydroquinoline-3-carbonitrile 
• 364793-52-2 6-bromo-4-hydroxyquinoline-3-carbonitrile 

Downstream Products

• 946491-05-0 6-bromo-4-((3,4,5-trimethoxyphenyl)amino)quinoline-3-carbonitrile 
• 1314687-82-5 6-bromoquinoline-3-carbonitrile 
• 798545-30-9 6-bromoquinoline-3-carboxylic acid 
• 364788-62-5 4-(2,4-dichloro-5-methoxy-phenylamino)-6-(5-formyl-thiophen-3-yl)-quinoline-3-carbonitrile 
• 928779-61-7 4-(3-Chloro-4-fluoro-phenylamino)-6-((E)-styryl)-quinoline-3-carbonitrile 

Relevant articles and documents

PAPD5 INHIBITORS AND METHODS OF USE THEREOF

The present application provides compounds that are PAPD5 inhibitors and are useful in treating a variety of conditions such as cancer, telomere diseases, and aging-related and other degenerative disorders.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.

Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors

Synthesis and structure-activity relationship of a series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitrile derivatives as EGFR inhibitors is described. Compounds 29 and 30 showed potent in vitro inhibitory activity in the enzymatic assay as well as in the functional cellular assay. They are moderately selective against other types of tyrosine kinases.