364794-79-6

Basic information

• Product Name: 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE
• Synonyms: Morpholine, 4-[[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]Methyl]-;4-[(Morpholin-4-yl)methyl]benzeneboronic acid, pinacol ester;4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}morpholine;4-(METHYLMORPHOLINO)PHENYLBORONIC ACID, PINACOL ESTER;4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE;4-(4-METHYLMORPHOLINE)BENZENEBORONIC ACID, PINACOL ESTER;4-(4-MORPHOLINOMETHYL)PHENYLBORONIC ACID PINACOL ESTER, 97%;4-(4-Morpholinylmethyl)benzeneboronic acid pinacol ester, 97%
• CAS NO: 364794-79-6
• Molecular Formula: C₁₇H₂₆BNO₃
• Molecular Weight: 303.2
• Product Categories: Boronate Esters;Boronic Acids and Derivatives;Chemical Synthesis;Organometallic Reagents;Aryl Boronate Esters
• Mol File: 364794-79-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 76-78
• Boiling Point: 400.8°Cat760mmHg
• Flash Point: 196.2°C
• Appearance: /
• Density: 1.08
• Vapor Pressure: 1.24E-06mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 6.49±0.10(Predicted)
• CAS DataBase Reference: 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE(364794-79-6)
• EPA Substance Registry System: 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE(364794-79-6)

Safety Data

• Hazard Codes: C
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• WGK Germany: 3
• Hazardous Substances Data: 364794-79-6(Hazardous Substances Data)

Usage

General Description

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]morpholine is a complex chemical compound that is a part of a group of compounds known as organoboranes. As the name suggests, this chemical consists of a morpholine ring, a benzyl group and a tetramethyl-1,3,2-dioxaborolan-2-yl group. Organoboranes, like this compound, are often used in organic chemistry for various types of reactions and syntheses, due to their unique chemical properties. The specific properties, uses and potential hazards of this specific compound are dependent on its exact molecular structure and would need to be determined from empirical data. However, it is likely to be used primarily in research and industrial applications.

InChI:InChI=1/C17H26BNO3/c1-16(2)17(3,4)22-18(21-16)15-7-5-14(6-8-15)13-19-9-11-20-12-10-19/h5-8H,9-13H2,1-4H3

Upstream product

• 106-38-7 para-bromotoluene 
• 110-91-8 morpholine 
• 138500-85-3 4-bromomethylphenylboronic acid pinacol ester 
• 73183-34-3 bis(pinacol)diborane 
• 364793-86-2 4-(3-bromophenethyl)morpholine 
• 1122-91-4 4-bromo-benzaldehyde 
• 132833-51-3 4-[(4-bromophenyl)methyl]morpholine 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 302348-51-2 (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 

Downstream Products

• 1404051-58-6 (R)-4-[4-[5-[1-[quinuclidin-3-yl]-1H-1,2,3-triazol-4-yl]-2-thienyl]phenyl]methyl morpholine 
• 1202486-22-3 N-(4-(4-methylpiperazin-1-yl)phenyl)-5-(4-(morpholinomethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine 
• 1202490-78-5 N-(4-chlorophenyl)-5-(4-(morpholinomethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine 

Relevant articles and documents

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

[1,2,4]triazol[1,5-a]pyridine compound as well as preparation method and medical application thereof

The invention relates to a [1,2,4]triazol[1,5-a] pyridine compound as well as a preparation method and medical application thereof. Particularly, the invention relates to the compound shown in a general formula I, the preparation method of the compound, a

Cell membrane permeable fluorescent perylene bisimide derivatives for cell lysosome imaging

We have developed acid activated fluorescent probes based on amphiphilic perylene bisimide with morpholine groups on the bay (Lyso-APBI). Incorporating one morpholine group, Lyso-APBI-1 showed an acid activated fluorescence increase of 70-fold upon pH values lowering from 8.0 to 4.0. Lyso-APBI-2, with two morpholine groups on the bay of PBI, had a red-shifted emission and a 190-fold fluorescence enhancement within same pH variation range. These Lyso-APBI probes have excellent membrane permeability, low cytotoxicity, and can rapidly accumulate and specifically activate in cell lysosomes. The double morpholine moieties make Lyso-APBI probes have higher acid activation ratio and better cell lysosome specificity. Moreover, long-time cell imaging proved the relatively high photostability of Lyso-APBI probes in a harsh physiological environment.