36482-37-8Relevant articles and documents
(S)-(-)-α-Methylbenzylamine as chiral auxiliary in the synthesis of (+)-lortalamine
Pawlowska, Jolanta,Krawczyk, Krzysztof K.,Wojtasiewicz, Krystyna,Maurin, Jan K.,Czarnocki, Zbigniew
, p. 83 - 86 (2009)
(+)-Lortalamine was synthesised using (S)-(-)-α-methylbenzylamine as a chiral auxiliary. The stereochemistry of an intermediate compound was established on the basis of X-ray crystallography, allowing unambiguous assignment of the absolute configuration.
BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS
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Page/Page column 163-164; 168-169, (2017/12/18)
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
Synthesis and antihistamine evaluations of novel loratadine analogues
Wang, Yue,Wang, Juan,Lin, Yan,Si-Ma, Li-Feng,Wang, Dong-Hua,Chen, Li-Gong,Liu, Deng-Ke
, p. 4454 - 4456 (2011/09/15)
A series of loratadine analogues containing hydroxyl group and chiral center were synthesized. The effect of the synthesized compounds on the histamine-induced contractions of guinea-pig ileum muscles was studied. In addition, the in vivo asthma-relieving effect of the analogues in the histamine induced asthmatic reaction in guinea-pigs was determined. Most of the compounds exhibited definite H1 antihistamine activity. The S-enantiomers, compounds 2, 4 and 8, are more potent than the R-enantiomers, compounds 1, 3 and 7. Compound 6 was the most active one among the eight synthesized compounds.