26822-37-7

Usage

Uses

Used in Organic Synthesis:
PIPERIDINIUM, 1,1-DIMETHYL-4-OXO-, IODIDE is used as a phase-transfer catalyst for facilitating the transfer of reactants between immiscible phases during chemical reactions. Its ability to improve reaction efficiency and selectivity makes it a valuable component in various organic synthesis processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, PIPERIDINIUM, 1,1-DIMETHYL-4-OXO-, IODIDE has potential applications in the development and production of various organic compounds. Its unique properties and reactivity contribute to the creation of new pharmaceutical agents and drug formulations.
Used in Chemical Research:
PIPERIDINIUM, 1,1-DIMETHYL-4-OXO-, IODIDE is also utilized in chemical research to explore its properties, reactivity, and potential applications in different chemical reactions and processes. This helps in expanding the understanding of its role in organic chemistry and discovering new uses for PIPERIDINIUM, 1,1-DIMETHYL-4-OXO-, IODIDE.

InChI:InChI=1/C7H14NO/c1-8(2)5-3-7(9)4-6-8/h3-6H2,1-2H3/q+1

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 74-88-4 methyl iodide 
• 25012-72-0 ethyl 1-methyl-4-oxo-piperidin-3-carboxylate 
• 13221-89-1 1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 105-71-5 3-methyl[(3-methoxy-3-oxopropyl)methylamino]propanoate 
• 41661-47-6 piperidin-4-one 
• 108-20-3 di-isopropyl ether 

Downstream Products

• 36482-37-8 N-<(S)-α-methylbenzyl>-4-piperidone 
• 263143-80-2 N-[(1'S,2'R)-2'-tert-butyldimethylsiloxy-1'-methyl-2'-phenylethyl]piperidin-4-one 
• 1465-76-5 1-tert-butyl-piperidin-4-one 
• 55854-97-2 3,4,6,7,12,12b-Hexahydro-1H-indolo[2,3-a]quinolizin-2-one 
• 2114-90-1 methyl (16α)-17-oxoyohimban-16-carboxylate 
• 84-37-7 (+/-)-β-yohimbine 
• 84-37-7 3α-15α-20β-17α-hydroxylyohimbine-16α-carboxylic acid methyl ester 
• 214613-86-2 1-(2-fluorophenethyl)piperidin-4-one 
• 1590400-05-7 (11R,7S)-(+)-8-(1-phenylethyl)-1,4-dioxa-8-azaspiro[4.5]decane-7-carbonitrile 
• 1590400-44-4 (11R,7R)-(+)-8-(1-phenylethyl)-1,4-dioxa-8-azaspiro[4.5]decane-7-carbonitrile 
• 1590400-93-3 (11S,7R)-(-)-8-(1-phenylethyl)-1,4-dioxa-8-azaspiro[4.5]decane-7-carbonitrile 
• 1590400-02-4 (11R)-(+)-8-(1-phenylethyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 1590400-91-1 (11S)-(-)-8-(1-phenylethyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 120343-66-0 (R)-1-(1-phenylethyl)tetrahydro-4(1H)-pyridinone 

Relevant academic research and scientific papers

SUBSTITUTED 3-((3-AMINOPHENYL)AMINO)PIPERIDINE-2,6-DIONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, X, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

Synthesis and Antimicrobial Evaluation of Novel Chiral 2-Amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Derivatives

New N-substituted-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives were synthesized employing a convenient one-pot three-component method and their structures were characterized by 1H-NMR and single crystal X-ray diffraction analysis. All the synthesized compounds were in vitro screened for antimicrobial activity against Gram-positive (Sarcina lutea) and Gram-negative bacteria (Escherichia coli). In this work, we introduced a chiral residue on the tetrahydropyridine nitrogen, the hitherto the less investigated position on this pharmacophore in order to explore the effect. The antibacterial results showed that the synthesized compounds were active only against Gram-positive bacteria and the (R)-enantiomers displayed a greater antimicrobial potency than their (S)-counterparts. The structure–activity relationship here investigated may provide some interesting clues for future development of tetrahydrothienopyridine derivatives with higher antimicrobial activity.

Protein labelling and albumin binding characteristics of the near-IR Cy7 fluorophore, QuatCy

Free cysteine residues react with QuatCy 1, by simply mixing the protein and dye in aqueous buffer at 37 °C. Another dye, MHI-148, can be used for a similar labelling protocol, but QuatCy reacts faster with all proteins studied, except albumin; it emerges here that this is because MHI-148 instantly forms of a non-covalent complex with albumin, but QuatCy does not. Labelling with QuatCy has advantages insofar as it is over five times brighter, and much more photostable, than MHI-148, and combination labelling with this dye pair will allow multiplexing in the near-IR region.

CONJUGATES OF KINASE INHIBITORS AND CYANINE DYES

The present disclosure provides conjugates of kinase inhibitors and cyanine dyes, as well as related compositions, methods and uses.

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2

Tuberculosis (TB) caused by the pathogen Mycobacterium tuberculosis, represents one of the most challenging threat to public health worldwide, and with the increasing resistance to approved TB drugs, it is needed to develop new strategies to address this

Fused tricyclic hepatitis virus inhibitor and application thereof

The invention belongs to the field of medical chemistry, relates to a fused tricyclic hepatitis virus inhibitor and application thereof, and particularly, provides a compound of the general formula I or pharmaceutically acceptable salt, isomer, solvate, crystal or prodrug thereof, and a medicine composition containing the compounds and application of the compounds or the composition in medicine preparation. The compound has the good inhibiting activity on hepatitis C virus, meanwhile has the low toxicity on host cells, and is high in effectiveness, good in safety and likely to become the medicine for treating and/or preventing diseases relevant to HCV infection.

Electrochemical access to 8-(1-phenyl-ethyl)-1,4-dioxa-8-aza-spiro[4.5] decane-7-carbonitrile. Application to the asymmetric syntheses of (+)-myrtine and alkaloid (+)-241D

The total syntheses of both enantiomers of trans-quinolizidine (+)-myrtine and cis-2,4,6-trisubstituted piperidine alkaloid (+)-241D are reported here. Our approach was based on the N-Boc-directed metalation of enantiopure 4-piperidone (-)-11, which was prepared in four steps from α-amino nitrile 6 through a stereoselective alkylation-reduction decyanation process. α-Amino nitrile 6 was prepared at the anode through electrochemical oxidation of 4-piperidone (+)-5. In our study, α-phenylethylamine (α-PEA) allowed an efficient 1-3 stereoinduction, and an orthogonal cleavage of the N-Boc protecting group in piperidone derivatives was carried out by stirring them in a suspension of SnCl4·(Et2O)2 complex in diethyl ether. When appropriate, the ers were determined by proton and carbon NMR spectroscopy utilizing (+)-tert-butylphenylphosphinothioic acid and (+)-DBTA as chiral solvating agents.

Spiroalkene carboxamide derivatives and their use as chemokine receptor modulators

The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.

SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS

The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.