365-29-7

Basic information

• Product Name: N-(2,3,4-trifluorophenyl)acetaMide
• Synonyms: N-(2,3,4-trifluorophenyl)acetaMide;2',3',4'-Trifluoroacetanilide
• CAS NO: 365-29-7
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.1345496
• Mol File: 365-29-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,3,4-trifluorophenyl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3,4-trifluorophenyl)acetaMide(365-29-7)
• EPA Substance Registry System: N-(2,3,4-trifluorophenyl)acetaMide(365-29-7)

Safety Data

• Hazardous Substances Data: 365-29-7(Hazardous Substances Data)

Usage

General Description

N-(2,3,4-trifluorophenyl)acetamide is a chemical compound with the formula C8H6F3NO. It is an organic amide, which means it contains the carbonyl group attached to an amine group. N-(2,3,4-trifluorophenyl)acetaMide is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Due to the presence of the trifluorophenyl group, it is also commonly used as a building block in the development of new materials, especially in the field of organic electronics. N-(2,3,4-trifluorophenyl)acetamide is known for its strong electron-withdrawing properties, making it useful in a wide range of chemical reactions and applications.

Upstream product

• 3862-73-5 2,3,4-trifluoroaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 168966-54-9 3,4,5-Trifluoro-1,2-phenylenediamine 
• 290313-50-7 6-nitro-2,3,4-trifluoroacetanilide 
• 587847-30-1 4,5,6-trifluoro-2-nitrophenylazide 
• 148416-38-0 6-nitro-2,3,4-trifluoroaniline 

Relevant articles and documents

An Improved and Efficient N-acetylation of Amines Using Choline Chloride Based Deep Eutectic Solvents

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Synthesis of novel fluorobenzofuroxans by oxidation of anilines and thermal cyclization of arylazides

The synthesis of several fluorobenzofuroxans by oxidation of fluoroanilines and thermal cyclization of fluoroarylazides is presented. The fluorobenzofuroxans prepared in this study presented tautomerism as evidenced by their NMR data. Benzofuroxans in general have biological activity and are synthetic intermediates for the preparation of several compounds with important pharmaceutical applications.

Synthesis and structure-activity relationships of substituted 1,4- dihydroquinoxaline-2,3-diones: Antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors

A series of mono-, di-, tri-, and tetrasubstituted 1,4- dihydroquinoxaline-2,3-diones (QXs) were synthesized and evaluated as antagonists at N-methyl-D-aspartate (NMDA)/glycine sites and α-amino-3- hydroxy-5-methylisoxazole-4-propionic acid-preferring non-NMDA receptors. Antagonist potencies were measured by electrical assays in Xenopus oocytes expressing rat whole brain poly(A)+ RNA. Trisubstituted QXs 17a (ACEA 1021), 17b (ACEA 1031), 24a, and 27, containing a nitro group in the 5 position and halogen in the 6 and 7 positions, displayed high potency (K(b) ~ 6-8 nM) at the glycine site, moderate potency at non-NMDA receptors (K(b) = 0.9-1.5 μM), and the highest (120-250-fold) selectivity in favor of glycine site antagonism over non-NMDA receptors. Tetrasubstituted QXs 17d,e were more than 100-fold weaker glycine site antagonists than the corresponding trisubstituted QXs with F being better tolerated than Cl as a substituent at the 8 position. Di- and monosubstituted QXs showed progressively weaker antagonism compared to trisubstituted analogues. For example, removal of the 5-nitro group of 17a results in a ~100-fold decrease in potency (10a,b,z), while removal of both halogens from 17a results in a ~3000-fold decrease in potency (10v). In terms of steady-state inhibition, most QX substitution patterns favor antagonism at NMDA/glycine sites over antagonism at non-NMDA receptors. Among the QXs tested, only 17i was slightly selective for non- NMDA receptors.