36519-50-3

Basic information

• Product Name: C₆H₄C(OH)(C₆H₅)N(CH₂C₆H₅)C₆H₄
• Synonyms: C₆H₄C(OH)(C₆H₅)N(CH₂C₆H₅)C₆H₄
• CAS NO: 36519-50-3
• Molecular Weight: 363.459
• Mol File: 36519-50-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₆H₄C(OH)(C₆H₅)N(CH₂C₆H₅)C₆H₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₆H₄C(OH)(C₆H₅)N(CH₂C₆H₅)C₆H₄(36519-50-3)
• EPA Substance Registry System: C₆H₄C(OH)(C₆H₅)N(CH₂C₆H₅)C₆H₄(36519-50-3)

Safety Data

• Hazardous Substances Data: 36519-50-3(Hazardous Substances Data)

Upstream product

• 60536-21-2 10-benzylacridine-9(10H)-one 
• 100-58-3 phenylmagnesium bromide 
• 100-44-7 benzyl chloride 
• 578-95-0 10H-acridin-9-one 
• 947700-71-2 C₂₇H₂₃NO 
• 947700-70-1 C₂₇H₂₃NO 

Downstream Products

• 60536-21-2 10-benzylacridine-9(10H)-one 
• 155816-67-4 4-phenylnonan-2-one 
• 23426-03-1 3,3-diphenylpropanoic acid methyl ester 
• 947700-71-2 C₂₇H₂₃NO 
• 881662-42-6 Rh((R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)(C₆H₅)(P(C₆H₅)3) 
• 947700-85-8 Rh((R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl))C₆H₄)(P(C₆H₅)2) 

Relevant articles and documents

N-substituted phenoxazine and acridone derivatives: Structure-activity relationships of potent P2X4 receptor antagonists

P2X4 receptor antagonists have potential as drugs for the treatment of neuropathic pain and neurodegenerative diseases. In the present study the discovery of phenoxazine derivatives as potent P2X4 antagonists is described. N-Substituted phenoxazine and related acridone and benzoxazine derivatives were synthesized and optimized with regard to their potency to inhibit ATP-induced calcium influx in 1321N1 astrocytoma cells stably transfected with the human P2X4 receptor. In addition, species selectivity (rat, mouse, human) and receptor subtype selectivity (versus P2X1,2,3,7) were investigated. The most potent P2X4 antagonist of the present series was N-(benzyloxycarbonyl)phenoxazine (26, PSB-12054) with an IC50 of 0.189 μM and good selectivity versus the other human P2X receptor subtypes. N-(p-Methylphenylsulfonyl)phenoxazine (21, PSB-12062) was identified as a selective P2X4 antagonist that was equally potent in all three species (IC50: 0.928-1.76 μM). The compounds showed an allosteric mechanism of action. The present study represents the first structure-activity relationship analysis of P2X4 antagonists.