23426-03-1

Upstream product

• 186581-53-3 diazomethane 
• 606-83-7 3,3-Diphenylpropionic acid 
• 67-56-1 methanol 
• 13294-63-8 3-chloro-1,1-diphenyl-acetone 
• 124-41-4 sodium methylate 
• 32858-84-7 β-hydroxy-β,β-diphenyl-methyl propionate 
• 591-50-4 iodobenzene 
• 103-26-4 methyl cinnamate 
• 3220-49-3 phenyl copper 
• 603-36-1 triphenylantimony 
• 934-56-5 trimethyl(phenyl)stannane 
• 103-26-4 Methyl cinnamate 
• 98-80-6 phenylboronic acid 
• 603-33-8 triphenylbismuthane 

Downstream Products

• 24647-01-6 2-benzhydryl-3-oxo-5,5-diphenyl-valeric acid methyl ester 
• 606-83-7 3,3-Diphenylpropionic acid 
• 41140-53-8 1-Methanesulfonyloxy-3,3-diphenylpropane 
• 22156-48-5 3,3-diphenylpropionitrile 
• 38151-56-3 4,4-diphenylbutyraldehyde 
• 13042-18-7 Fendiline 
• 1145781-03-8 methyl 3-[4-(2-methylpropionyl)phenyl]-3-phenylpropanoate 
• 1145781-14-1 methyl3-phenyl-3-[4-(cyclohexylcarbonyl)phenyl]propionate 
• 37089-77-3 3,3-diphenylpropanoyl chloride 
• 16618-72-7 3-phenyl-1-indanone 
• 252770-39-1 1-(3,3-dimethyl-2-oxo-pentanoyl)-piperidine-2-carbothioic acid S-(3,3-diphenyl-propyl) ester 
• 205388-30-3 3,3-diphenyl-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarbothioate 
• 454484-95-8 3,3-diphenylpropane-1-thiol 
• 20017-68-9 1-bromo-3,3-diphenylpropane 

Relevant academic research and scientific papers

Rhodium-Catalyzed meta-Selective C?H Carboxylation Reaction of 1,1-Diarylethylenes via Hydrorhodation-Rhodium Migration

A meta-selective C?H carboxylation reaction of 1,1-diarylethylene derivatives with CO2 by using a rhodium catalyst with NaOiPr as a stoichiometric reductant has been achieved. Together with hydrogenation of the ethylene moiety, a carboxyl group was introduced to the meta-position of the aryl ring with high selectivity over the ortho-positions. Experimental and computational mechanistic studies indicate that this carboxylation reaction proceeds via hydrorhodation on the ethylene moiety, followed by 1,4-rhodium migration and successive 1,2-rhodium migration on the aryl ring. The use of a bulky phosphine ligand seems to be the key to this unusual aryl-to-aryl 1,2-rhodium shift.

Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Aryl Iodides to Enals

An umpolung 1,4-addition of aryl iodides to enals promoted by cooperative (terpy)Pd/NHC catalysis was developed that generates various bioactive β,β-diaryl propanoate derivatives. This system is not only the first reported palladium-catalyzed arylation of NHC-bound homoenolates but also expands the scope of NHC-induced umpolung transformations. A diverse array of functional groups such as esters, nitriles, alcohols, and heterocycles are tolerated under the mild conditions. This method also circumvents the use of moisture-sensitive organometallic reagents.

C-C Bond Cleavage of Unactivated 2-Acylimidazoles

2-Acylimidazoles are widely used as post-Transformable carboxylic acid equivalents in chemoselective and enantioselective reactions. Their transformations, however, require pretreatment with highly reactive, toxic methylating reagents to facilitate C-C bond cleavage. Here, we demonstrate that such pretreatment can be avoided and the C-C bond cleaved under neutral conditions without the use of additional reagents or catalysts. The scope of the reaction, including the use of products reported in the literature as substrates, and some mechanistic insights are described.

Visible-Light-Driven Reductive Carboarylation of Styrenes with CO2 and Aryl Halides

The first example of visible-light-driven reductive carboarylation of styrenes with CO2 and aryl halides in a regioselective manner has been achieved. A broad range of aryl iodides and bromides were compatible with this reaction. Moreover, pyridyl halides, alkyl halides, and even aryl chlorides were also viable with this method. These findings may stimulate the exploration of novel visible-light-driven Meerwein arylation-addition reactions with user-friendly aryl halides as the radical sources and the photocatalytic utilization of CO2

Synthetic method of beta, beta-disubstituted propionate derivative

The invention discloses a synthetic method of beta, beta-disubstituted propionate derivative, and belongs to the field of organic synthesis. An aldehyde compound, an iodide and an alcohol are adoptedto synthesize the beta, beta-disubstituted propionate derivative through a one-pot method, and the synthetic method is used for realizing beta-bit arylation and esterification of carbonyl groups of alpha, beta-unsaturated aldehyde to synthesize beta, beta-disubstituted methyl propionate. The synthesis steps of a traditional method are reduced, the reaction yield is increased, and according to thesynthetic method, raw materials are cheap, the operation steps are simple, the reaction condition is mild, and applicability of reaction substrates is greatly enriched.

Phenoxy-Dialkoxy Borates as a New Class of Readily Prepared Preactivated Reagents for Base-Free Cross-Coupling

One of the most useful chemical transformations of organoboronic acids is the Suzuki–Miyaura cross-coupling reaction. Although it has vast application, it possesses some limitations: boronic acids can be difficult to quantify accurately due to their tendency to form oligomeric anhydrides and they must be activated under basic conditions. To address these problems, a new class of boronic acid derivatives is described. Phenoxy-dialkoxy borates are prepared under mild conditions and show good solubility in common organic solvents. These adducts can be used in base-free metal-catalysed cross-coupling reactions, including orthogonal reactions with MIDA boronates and trifluoroborates.

Catalytic Use of Low-Valent Cationic Gallium(I) Complexes as π-Acids

Transformations of alkene and alkyne substrates relevant to π-Lewis acid catalysis have been performed using low-valent Ga(I) species for the first time. [Ga(I)(PhF)2]+[Al(ORF)4]? and gallium dichloride (i. e. [Ga(I)]+[GaCl4]?) proved to be efficient catalysts for cycloisomerizations, Friedel-Crafts reactions, transfer hydrogenations, and reductive hydroarylations. Their activity is compared to more common Ga(III) complexes. This study shows that even the readily available and yet overlooked gallium dichloride salt can be a more active π-Lewis acid catalyst than gallium trichloride or other Ga(III) species. (Figure presented.).

Rhenium complex-catalyzed carbon-carbon formation of alcohols and organosilicon compounds

The coupling reactions of allylic and benzylic alcohols and allyltrimethylsilane are efficiently catalyzed by a rhenium complex to give the corresponding 1,5-dienes and alkenes in moderate to good yields. Similarly, alcohols were coupled with ketene silyl acetals to form the corresponding esters.

Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides

Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chemistry, and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, we report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcohols, affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.

Metal-Free Enantioselective Oxidative Arylation of Alkenes: Hypervalent-Iodine-Promoted Oxidative C?C Bond Formation

The enantioselective oxyarylation of (E)-6-aryl-1-silyloxylhex-3-ene was achieved using a lactate-based chiral hypervalent iodine(III) reagent in the presence of boron trifluoride diethyl etherate. The silyl ether promotes the oxidative cyclization, and enhances the enantioselectivity. In addition, the corresponding aminoarylation was achieved.