3652-45-7

Usage

Uses

Used in Pharmaceutical Research:
1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester is used as a key intermediate in the synthesis of new drugs and medicinal compounds. Its unique structure and properties make it a promising candidate for the development of innovative therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester serves as a versatile building block for the creation of various organic compounds. Its reactivity and functional groups allow for a wide range of chemical reactions, facilitating the synthesis of complex molecules.
Used in Material Science and Chemical Engineering:
Due to its unique structure and properties, 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester may have applications in material science and chemical engineering. Its potential use in the development of new materials or processes could contribute to advancements in these fields.

Upstream product

• 613-91-2 acetophenone oxime 
• 57957-24-1 N-(1-phenylvinyl)acetamide 
• 100-46-9 benzylamine 
• 4636-16-2 iodoacetophenone 
• 141-97-9 ethyl acetoacetate 
• 70-11-1 α-bromoacetophenone 
• 52313-46-9 ethyl 2-acetyl-4-oxo-4-phenylbutanoate 
• 3652-48-0 ethyl 2-methyl-5-phenyl-1H-pyrrole-3-carboxylate 
• 620-05-3 iodomethylbenzene 

Relevant academic research and scientific papers

Sonochemically assisted synthesis of N-substituted pyrroles catalyzed by ZnO nanoparticles under solvent-free conditions

Abstract: An efficient and rapid synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives from a one-pot multicomponent reaction of amines, 1,3-dicarbonyl compounds, and α-haloketones in the presence of ZnO nanoparticles catalyst under ultrasonic irradiation and solvent-free conditions is described. Graphical abstract: [Figure not available: see fulltext.].

Direct oxidative coupling of enamides and 1,3-dicarbonyl compounds: A facile and versatile approach to dihydrofurans, furans, pyrroles, and dicarbonyl enamides

An efficient manganese(III)-mediated oxidative coupling reaction between α-aryl enamides and 1,3-dicarbonyl compounds has been developed. A series of dihydrofurans and dicarbonyl enamides were synthesized in moderate to good yields. Moreover, these dihydrofurans could be readily transformed into the corresponding furans and pyrroles via the Paal-Knorr reaction.

Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: A generalization of the Hantzsch pyrrole synthesis

A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(iv) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone preparation with a general version of the classical Hantzsch pyrrole synthesis.

Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Arylpiperzine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated as novel antidepressant compounds. The various analogues were efficiently prepared and bio-assayed for binding to 5-HT2A, 5-HT2C receptor, and

One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert-butyl esters

The first one-step, continuous flow synthesis of pyrrole-3-carboxylic acids directly from tert-butyl acetoacetates, amines, and 2-bromoketones is reported. The HBr generated as a byproduct in the Hantzsch reaction was utilized in the flow method to hydrolyze the t-butyl esters in situ to provide the corresponding acids in a single microreactor. The protocol was used in the multistep synthesis of pyrrole-3-carboxamides, including two CB1 inverse agonists, directly from commercially available starting materials in a single continuous process.