3652-45-7

Basic information

• Product Name: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester
• CAS NO: 3652-45-7
• Molecular Formula: C21H21NO2
• Molecular Weight: 319.403
• Mol File: 3652-45-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester(3652-45-7)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester(3652-45-7)

Safety Data

• Hazardous Substances Data: 3652-45-7(Hazardous Substances Data)

Usage

General Description

1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester is a chemical compound with the molecular formula C21H20N2O2. It is an ethyl ester derivative of 1H-Pyrrole-3-carboxylic acid and is commonly used in organic synthesis and pharmaceutical research. 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-1-(phenylmethyl)-, ethyl ester contains a pyrrole ring with a methyl group and a phenyl group, along with an ethyl ester functional group. It has potential pharmacological properties and is being investigated for its potential use in the development of new drugs and medicinal compounds. Additionally, it may have applications in the field of material science and chemical engineering due to its unique structure and properties.

Upstream product

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Relevant articles and documents

Sonochemically assisted synthesis of N-substituted pyrroles catalyzed by ZnO nanoparticles under solvent-free conditions

Abstract: An efficient and rapid synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives from a one-pot multicomponent reaction of amines, 1,3-dicarbonyl compounds, and α-haloketones in the presence of ZnO nanoparticles catalyst under ultrasonic irradiation and solvent-free conditions is described. Graphical abstract: [Figure not available: see fulltext.].

Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: A generalization of the Hantzsch pyrrole synthesis

A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(iv) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone preparation with a general version of the classical Hantzsch pyrrole synthesis.

One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert-butyl esters

The first one-step, continuous flow synthesis of pyrrole-3-carboxylic acids directly from tert-butyl acetoacetates, amines, and 2-bromoketones is reported. The HBr generated as a byproduct in the Hantzsch reaction was utilized in the flow method to hydrolyze the t-butyl esters in situ to provide the corresponding acids in a single microreactor. The protocol was used in the multistep synthesis of pyrrole-3-carboxamides, including two CB1 inverse agonists, directly from commercially available starting materials in a single continuous process.