365261-27-4

Usage

Uses

Used in Organic Synthesis:
3-Bromo-1-methyl-1,2,5,6-tetrahydropyridine is used as a synthetic intermediate for the preparation of a wide range of organic compounds. Its unique structure allows for various chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Bromo-1-methyl-1,2,5,6-tetrahydropyridine is employed as a key component in the development of new drugs. Its structural features enable it to serve as a precursor to various pharmaceutical agents, contributing to the discovery and synthesis of novel therapeutic compounds.
Used in Drug Production:
3-Bromo-1-methyl-1,2,5,6-tetrahydropyridine is utilized in the manufacturing process of certain drugs and agrochemicals. Its presence in these products is attributed to its ability to enhance the pharmacological properties and effectiveness of the final product.
Used in Neuroscience and Neuropharmacology Research:
Due to its structural similarity to certain neurotransmitters and potential effects on the central nervous system, 3-Bromo-1-methyl-1,2,5,6-tetrahydropyridine may have applications in the field of neuroscience and neuropharmacology. Researchers are exploring its potential use in the development of treatments for neurological disorders and conditions affecting the central nervous system.

Upstream product

• 32222-42-7 3-bromo-N-methylpyridinium iodide 
• 28125-84-0 Homoarecoline 

Downstream Products

• 1254982-25-6 1-methyl-5-(4,4,4,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine 

Relevant academic research and scientific papers

Method for synthesizing N-substitute-1, 2, 3, 6-tetrahydropyridine-5-boric acid ester

The invention discloses a method for synthesizing N-substitute-1, 2, 3, 6-tetrahydropyridine-5-boric acid ester. According to the method, N-substitute-1, 2, 3, 6-tetrahydropyridine-5-carboxylic acid (ester) serves as the raw material, conducts addition with halogen and then is subjected to alkaline condition elimination to form alkenyl halide and then subjected to coupling with al boron ester under the condition of metal palladium catalyzation, and the N-substitute-1, 2, 3, 6-tetrahydropyridine-5-boric acid ester is obtained. According to the method, the obtained midbody alkenyl halide does not contain isomer, separation is easy to conduct, purity of an obtained product is high, and the method provides a simple way for synthesis of compounds of the type.

1-Methyl-1-azacyclohexa-2,3-diene(N-B)borane - Generation and interception of an unsymmetrical isodihydropyridine

3-Bromo-1-methyl-1,2,5,6-tetrahydropyridine(N-B)borane (7) was prepared from 3-bromopyridine by conversion to 3-bromo-1-methylpyridinium iodide, hydrogenation of the latter with sodium tetrahydroborate and treatment of the resulting 3-bromo-1-methyl-1,2,5,6-tetrahydropyridine (6) with borane-dimethyl sulfide. Whereas no trapping product of the possible intermediate 1-methyl-1-azacyclohexa-2,3-diene (4) could be observed on treatment of 6 with potassium tert-butoxide in the presence of furan, the subjection of 7 to the same conditions produced the hexahydroepoxyquinoline derivatives 8a-c. Treatment of 7, dissolved in styrene, with sodium bis(trimethylsilyl)amide furnished the hexahydrocyclobutapyridine derivatives 9a-c. The six-membered cycloallene 1-methyl-1-azacyclohexa-2,3-diene(N-B)borane (10) must be regarded as the key intermediate en route to 8 and 9.