28125-84-0

Usage

Uses

Used in Pharmaceutical Industry:
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid ethyl ester is used as a synthetic precursor for the development of new drug compounds, leveraging its chemical properties to facilitate the production of medications for diverse medical applications.
Used in Drug Synthesis:
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid ethyl ester is utilized as a crucial intermediate in the synthesis process of various pharmaceuticals, contributing to the formulation of effective treatments for an array of health issues.
Used in Ongoing Research:
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid ethyl ester is also used as a subject of research for its potential therapeutic effects, with ongoing studies exploring its applications in treating specific diseases, highlighting its importance in advancing medical science.

InChI:InChI=1/C9H15NO2/c1-3-12-9(11)8-5-4-6-10(2)7-8/h5H,3-4,6-7H2,1-2H3

Upstream product

• 499-04-7 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid 
• 37673-66-8 4-hydroxy-1-methyl-piperidine-3-carboxylic acid ethyl ester 
• 144-62-7 oxalic acid 
• 10129-58-5 3-(ethoxycarbonyl)-1-methylpyridin-1-ium iodide 
• 64-17-5 ethanol 
• 5166-67-6 ethyl 1-methylpiperidine-3-carboxylate 
• 470700-27-7 ethyl 1-methyl-3-(phenylsulfanyl)piperidine-3-carboxylate 
• 71962-74-8 Ethyl nipecotate 
• 470700-28-8 ethyl 1-methyl-3-(phenylsulfinyl)piperidine-3-carboxylate 
• 111509-87-6 Ethyl 3-methyl-2-oxo-6-vinyl-3,4,5,6-tetrahydro-2H-1,3-oxazine-5-carboxylate 

Downstream Products

• 1254982-25-6 1-methyl-5-(4,4,4,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine 
• 365261-27-4 3-bromo-1-methyl-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

Intriguing influence of the solvent on the regioselectivity of sulfoxide thermolysis in β-amino-α-sulfinyl esters

The sulfoxide thermolysis of the diastereoisomeric methyl (3R,4aS, 10aR)-6-methyl-3-methyl-3-(phenyl-sulfinyl)-1,2,3,4,4a,5,10,10a- octahydrobenzo[g]quinoline-3-carboxylates 3a and 3′b in toluene yields, by loss of benzenesulfenic acid, an almost 1:1 mixture of the vinylogous urethane 2b and the isomeric α-aminomethyl enoate 2a. When this elimination is performed in acetic acid, the enoate 2a is formed rather selectively. The same solvent effects on the regioselectivity of the elimination of benzenesulfenic acid are observed with a simple sulfoxide of ethyl piperidine-3-carboxylate (7).

Cholinergic agents: Effect of methyl substitution in a series of arecoline derivatives on binding to muscarinic acetylcholine receptors

Arecoline, arecaidine, and a series of derivatives, differing by the presence or absence of methyl groups at positions on the periphery of the molecule, were prepared, and their binding to muscarinic acetylcholine receptors was tested. On the basis of this study, muscarinic agonism for arecoline series is governed by strict structure-activity relationships, as previously observed for other agonist series. Only minor changes in nitrogen substitution were tolerated in the present series of arecoline derivatives.

2-OXOTETRAHYDRO-1,3-OXAZINE : A USEFUL INTERMEDIATE FOR THE PREPARATION OF TETRAHYDROPYRIDINE, INDOLIZIDINE, AND QUINOLIZIDINE SKELETONS

Conversion of 2-oxotetrahydro-1,3-oxazines into tetrahydropyridines was applied to the synthesis of indolizidine and quinolizidine alkaloids.