3654-49-7

Basic information

• Product Name: 1,5-Bis-(4-hydroxyphenyl)-1,4-pentadien-3-one
• Synonyms: BIS-1,5-(4-HYDROXYPHENYL)-1,4-PENTADIEN-3-ONE;1,5-Bis-(4-hydroxyphenyl)-1,4-pentadien-3-one;4,4'-DIHYDROXYSTYRYL KETONE;1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one;Bis-1,5-(4-Hydroxyphenyl)-1,4-dentadien-3-One;1,5-Di(p-hydroxyphenyl)-1,4-pentadien-3-one;1,5-Bis(4-hydroxyphenyl)penta-1,4-diene-3-one;(1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one
• CAS NO: 3654-49-7
• Molecular Formula: C₁₇H₁₄O₃
• Molecular Weight: 266.29
• EINECS: 222-896-4
• Product Categories: Pharmaceutical Intermediates
• Mol File: 3654-49-7.mol
• Article Data: 36

Chemical Properties

• Melting Point: 237-238 °C
• Boiling Point: 492.7 °C at 760 mmHg
• Flash Point: 265.8 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 2.49E-10mmHg at 25°C
• Refractive Index: 1.703
• PKA: 9.40±0.30(Predicted)
• CAS DataBase Reference: 1,5-Bis-(4-hydroxyphenyl)-1,4-pentadien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Bis-(4-hydroxyphenyl)-1,4-pentadien-3-one(3654-49-7)
• EPA Substance Registry System: 1,5-Bis-(4-hydroxyphenyl)-1,4-pentadien-3-one(3654-49-7)

Safety Data

• Hazardous Substances Data: 3654-49-7(Hazardous Substances Data)

Usage

General Description

1,5-Bis-(4-hydroxyphenyl)-1,4-pentadien-3-one, also known as curcumin, is a natural compound found in the spice turmeric. It is a polyphenol that has been studied for its potential health benefits, including anti-inflammatory and antioxidant properties. Curcumin is known for its bright yellow color and has been used in traditional medicine for centuries. Research has shown that it may have potential in treating a variety of conditions, such as arthritis, cancer, and neurodegenerative diseases. Many studies are ongoing to further understand the potential uses of curcumin and its effects on the human body.

InChI:InChI=1/C17H14O3/c18-15-7-1-13(2-8-15)5-11-17(20)12-6-14-3-9-16(19)10-4-14/h1-12,18-19H/b11-5+,12-6+

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 67-64-1 acetone 
• 123-54-6 acetylacetone 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 104-88-1 4-chlorobenzaldehyde 
• 946161-20-2 (1E,4E)-1,5-bis[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]penta-1,4-dien-3-one 

Downstream Products

• 918339-99-8 1,3-bis[4-(2-hydroxyethyloxy)benzylidene]acetone 
• 1214989-62-4 1,3-bis[4-(8-hydroxyoctyloxy)benzylidene]acetone 
• 1214989-60-2 1,3-bis[4-(4-hydroxybutyloxy)benzylidene]acetone 
• 1214989-63-5 1,3-bis[4-(10-hydroxydecyloxy)benzylidene]acetone 
• 1214989-61-3 1,3-bis[4-(6-hydroxyhexyloxy)benzylidene]acetone 
• 123203-31-6 (1E,4E)-1,5-bis[4-(allyloxy)phenyl]penta-1,4-dien-3-one 
• 10365-62-5 4,4'-pentanediyl-di-phenol 
• 94824-00-7 1.5-Di-(4-hydroxyphenyl)-3-hydroxypentane 

Relevant articles and documents

Mesophase behavior and DFT conformational analysis of new symmetrical diester chalcone liquid crystals

Synthesis, geometrical structures, conformational analysis, mesomorphic and optical characterizations of new angular chalcone liquid crystals, 4-(1,5-(3-oxopenta-1,4-dienyl))diphenyl bis-4-alkoxybenzoates, were investigated. These compounds contain chalcone core and diester phenyl rings attached to symmetrical terminal alkoxy chains with different number (n) of carbons from 6 to 16. Mesomorphic and optical properties were studied for the prepared homologues by differential scanning calorimetry (DSC) and polarized optical microscopy (POM). Elemental analyses, FT-IR, 1H, and 13C NMR spectroscopy were used for molecular structure confirmation. Density functional theory (DFT) theoretical calculations were estimated to confirm the experimental data and to deduce the most stable confirmal of prepared compounds. The results indicate that the stability of the conformers and the type of the mesophase are dependent on the length of the terminal alkoxy chains. Thermal parameters, dipole moments and polarizability of all estimated conformers were discussed. The relationships between the values of these parameters and the conformer type as well as the mesophase stability were illustrated.

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.

BENZOXAZINES WITH PHOTO-CURABLE LINKAGES, THERMOSETS THEREOF, AND PREPARATION OF THE SAME

The subject invention provides benzoxazines with photo-curable linkages, thermosets thereof, and preparation methods of the same. The compounds of the subject invention can be used in manufacture of many kinds of cross-linking polymer material, and the obtained material is improved in terms of many properties, especially high thermal properties. Moreover, the preparation method of the subject invention can precisely synthesize the targeted products by simply steps.