365428-05-3

Basic information

• Product Name: 2-(2-tert-butoxycarbonylaminopyridin-4-yl)-1-(4-fluoro-3-methylphenyl)ethanone
• Synonyms: 2-(2-tert-butoxycarbonylaminopyridin-4-yl)-1-(4-fluoro-3-methylphenyl)ethanone
• CAS NO: 365428-05-3
• Molecular Weight: 344.386
• Mol File: 365428-05-3.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-tert-butoxycarbonylaminopyridin-4-yl)-1-(4-fluoro-3-methylphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-tert-butoxycarbonylaminopyridin-4-yl)-1-(4-fluoro-3-methylphenyl)ethanone(365428-05-3)
• EPA Substance Registry System: 2-(2-tert-butoxycarbonylaminopyridin-4-yl)-1-(4-fluoro-3-methylphenyl)ethanone(365428-05-3)

Safety Data

• Hazardous Substances Data: 365428-05-3(Hazardous Substances Data)

Upstream product

• 455-84-5 4-fluoro-3-methylbonzoyl chloride 
• 325770-37-4 N-(4-fluoro-3-methylbenzoyl)propyleneimine 
• 90101-20-5 tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate 

Downstream Products

• 365428-32-6 2-(2-aminopyridin-4-yl)-2-bromo-1-(4-fluoro-3-methylphenyl)ethanone hydrobromide 
• 896737-59-0 4-[6-chloro-2-(4-fluoro-3-methylphenyl)imidazo[1, 2-b]pyridazin-3-yl]pyridin-2-amine 
• 896737-63-6 4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-amine 
• 896738-16-2 N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}benzamide 
• 896739-23-4 N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide 

Relevant articles and documents

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors

We identified novel potent inhibitors of p38 MAP kinase using structure-based design strategy. X-ray crystallography showed that when p38 MAP kinase is complexed with TAK-715 (1) in a co-crystal structure, Phe169 adopts two conformations, where one intera

JNK INHIBITOR

The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.